克雅氏病模拟阿尔茨海默病和路易体痴呆症-FDG PET 的 3D 立体定向表面投影的发现。
Creutzfeldt-Jakob Disease Mimicking Alzheimer Disease and Dementia With Lewy Bodies-Findings of FDG PET With 3-Dimensional Stereotactic Surface Projection.
机构信息
From the Department of PET Center, Kofu Neurosurgical Hospital, Kofu, Yamanashi, Japan.
出版信息
Clin Nucl Med. 2017 May;42(5):e247-e248. doi: 10.1097/RLU.0000000000001602.
A 78-year-old man received a diagnosis of sporadic Creutzfeldt-Jakob disease based on symptoms and findings of MRI, FDG PET, and cerebrospinal fluid markers. PET with 3-dimensional stereotactic surface projection (3D-SSP) showed that the distribution of hypometabolism mimicked that of Alzheimer disease. A 68-year-old woman was treated under a diagnosis of convulsion. Findings of MRI, PET, familial history, and cerebrospinal fluid markers revealed familial Creutzfeldt-Jakob disease. FDG PET with 3D-SSP disclosed that the hypometabolic pattern mimicked that of dementia with Lewy bodies. FDG PET with 3D-SSP can demonstrate similar patterns in various neurodegenerative disorders.
一位 78 岁男性患者因症状和 MRI、FDG PET 及脑脊液标志物检查而诊断为散发性克雅氏病。采用三维立体定位表面投影（3D-SSP）的 PET 显示，代谢低下的分布类似于阿尔茨海默病。一位 68 岁女性因癫痫发作而接受治疗。MRI、PET、家族史和脑脊液标志物检查结果显示为家族性克雅氏病。采用 3D-SSP 的 FDG PET 显示，代谢低下的模式类似于路易体痴呆。采用 3D-SSP 的 FDG PET 可以显示各种神经退行性疾病中相似的模式。
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