Gorostegi-Anduaga Ilargi, Pérez-Asenjo Javier, Aispuru Gualberto Rodrigo, Fryer Simon M, Alonso-Colmenero Ainara, Romaratezabala Estíbaliz, Maldonado-Martín Sara
aLaboratory of Performance Analysis in Sport, Department of Physical Education and Sport, Faculty of Education and Sport-Physical Activity and Sport Section, University of the Basque Country (UPV/EHU) bCardiology Unit, IMQ group, Vitoria-Gasteiz cClinical Trials Unit, Health and Quality of Life, Tecnalia, Vitoria-Gasteiz dNutrition, Exercise and Health Research Group, Elikadura, Ariketa Fisikoa eta Osasuna, ELIKOS group (UPV/EHU), Vitoria ePrimary Care Administration of Burgos, Burgos, Spain fSchool of Sport and Exercise, University of Gloucestershire, Oxstalls Campus, Gloucester, UK.
Blood Press Monit. 2017 Jun;22(3):154-160. doi: 10.1097/MBP.0000000000000247.
Hypertension (HTN), obesity and low cardiorespiratory fitness (CRF) are associated with an increased risk for a cardiovascular event. Enrolling overweight/obese individuals with HTN, the current study aimed to estimate cardiovascular risk (CVR) and vascular age (VA) profiles analyzing potential sex differences, determine whether VA is higher than chronological age, and whether CVR is associated with a low level of CRF.
Overweight/obese non-Hispanic White participants (n=209; 141 men and 68 women) with primary HTN had their CVR and VA determined using the New Pooled Cohort Risk Equations and The Framingham method, respectively. Considering values of peak oxygen uptake, participants were divided into tertiles for each sex.
The CVR, but not VA (P=0.339), was higher (P<0.001) in men compared with women irrespective of age. Irrespective of sex, VA was higher than chronological age (P<0.001). Age and BMI were higher (P<0.05) in the low CRF group compared with that in other groups. There were no differences in CVR (P=0.907) and VA (P=1.643) when values were separated into CRF groups.
Pooled Cohort Equations could underestimate the risk of suffering a cardiovascular event in the following 10 years in overweight/obese non-Hispanic White women with HTN compared with men. The VA appears to be a useful tool in communicating CVR in this population irrespective of sex. The CRF alone may not be enough to moderate the CVR.
高血压（HTN）、肥胖和低心肺适能（CRF）与心血管事件风险增加相关。本研究纳入超重/肥胖的高血压患者，旨在评估心血管风险（CVR）和血管年龄（VA）概况，分析潜在的性别差异，确定VA是否高于实际年龄，以及CVR是否与低水平的CRF相关。
超重/肥胖的非西班牙裔白人原发性高血压参与者（n = 209；141名男性和68名女性）分别使用新合并队列风险方程和弗雷明汉方法确定其CVR和VA。根据峰值摄氧量值，将每个性别的参与者分为三分位数。
无论年龄如何，男性的CVR高于女性（P < 0.001），但VA无差异（P = 0.339）。无论性别如何，VA均高于实际年龄（P < 0.001）。低CRF组的年龄和体重指数高于其他组（P < 0.05）。按CRF分组时，CVR（P = 0.907）和VA（P = 1.643）无差异。
与男性相比，合并队列方程可能低估超重/肥胖的非西班牙裔白人高血压女性未来10年发生心血管事件的风险。无论性别如何，VA似乎是该人群中传达CVR的有用工具。仅CRF可能不足以调节CVR。
