Horiba N, Nomura K, Hizuka N, Takano K, Demura H, Shizume K
Department of Medicine, Tokyo Women's Medical College, Japan.
Endocrinol Jpn. 1987 Aug;34(4):611-4. doi: 10.1507/endocrj1954.34.611.
In a primary culture of bovine adrenal zona glomerulosa cells, insulin-like growth factor I (IGF-I)/somatomedin C stimulated DNA synthesis, as measured by [3H] thymidine uptake, at concentrations of 10(-9) and 10(-7) M. IGF-I also prevented ACTH-induced suppression of [3H] thymidine uptake. IGF-I in no way affected aldosterone secretion during short-term exposure to cultured cells, however. Our findings suggest that IGF-I plays an important role in the proliferation of adrenal zona glomerulosa cells.
