Porter C D, Muhlemann M F, Cream J J, Archard L C
Department of Biochemistry, Charing Cross and Westminster Medical School, London.
Epidemiol Infect. 1987 Oct;99(2):563-6. doi: 10.1017/s0950268800068072.
Restriction endonuclease analysis of molluscum contagiosum virus DNA revealed two subtypes. In a study of 46 isolates from 41 patients, some with no other disorder and some with atopic dermatitis, the ratio of MCV I isolates to MCV II was 34:12. Multiple clustered lesions removed at the same time from an individual patient yielded only one type of MCV. Lesions induced by MCV I or MCV II were indistinguishable on the basis of size and form. Neither subtype was associated exclusively with lesions at certain sites or with other clinical features. Heterogeneity of DNA restriction endonuclease cleavage patterns amongst isolates of the same subtype was observed, this being greatest for MCV II.
传染性软疣病毒DNA的限制性内切酶分析显示出两种亚型。在一项对41名患者的46株病毒分离株的研究中，有些患者无其他疾病，有些患有特应性皮炎，MCV I分离株与MCV II的比例为34:12。从单个患者身上同时切除的多个簇状病变仅产生一种类型的MCV。基于大小和形态，由MCV I或MCV II引起的病变无法区分。两种亚型均未仅与某些部位的病变或其他临床特征相关。在同一亚型的分离株中观察到DNA限制性内切酶切割模式的异质性，这在MCV II中最为明显。
