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尤因肉瘤中碱性磷酸酶和乳酸脱氢酶的血清值

SERUM VALUES OF ALKALINE PHOSPHATASE AND LACTATE DEHYDROGENASE IN EWING'S SARCOMA.

作者信息

Baptista André Mathias, Zumárraga Juan Pablo, Dos Santos Renan Pires Negrão, Haubert Guilherme de Oliveira, de Camargo Olavo Pires

机构信息

. Universidade de São Paulo, Faculdade de Medicina, Hospital das Clínicas, Institute of Orthopedics and Traumatology, São Paulo, SP, Brazil.

. Hospital Regional do Gama, Orthopedics and Traumatology Unit, Brasília, DF, Brazil.

出版信息

Acta Ortop Bras. 2016 Jul-Aug;24(4):196-199. doi: 10.1590/1413-785220162404161312.

DOI:10.1590/1413-785220162404161312
PMID:28243173
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5035691/
Abstract

OBJECTIVE

To study the relationship between the serum levels of alkaline phosphatase (AP) and lactate dehydrogenase (LDH), and the percentage of tumor necrosis (TN) in patients with Ewing´s Sarcoma (ES)

METHODS

This is a case series with retrospective evaluation of patients with diagnosis of ES divided into 2 groups: Group 1, patients whose serum levels of alkaline phosphatase (ALP) and lactate dehydrogenase (LDH) were obtained in the staging phase before preoperative chemotherapy (CT), and Group 2, patients whose values were measured after completion of the preoperative CT. The percentage of tumor necrosis (TN) of surgical specimens extracted in surgery was also evaluated

RESULTS

Eighty four medical records from 1995 to 2015 were included. Both AP as LDH decreased in the patients studied, the pre CT value being higher than the post CT value. The average decrease of LHD was 272.95 U/L and AP was 10.17 U/L. The average tumor necrosis was 65.12 %. There was no statistical correlation between serums levels and the tumor necrosis percentage

CONCLUSION

The serum levels values of AP and LDH are not predictors for chemotherapy-induced necrosis in patients with ES.

摘要

目的

研究尤因肉瘤（ES）患者血清碱性磷酸酶（AP）和乳酸脱氢酶（LDH）水平与肿瘤坏死百分比（TN）之间的关系。

方法

这是一个病例系列，对诊断为ES的患者进行回顾性评估，分为两组：第1组，术前化疗（CT）分期阶段获得血清碱性磷酸酶（ALP）和乳酸脱氢酶（LDH）水平的患者；第2组，术前CT完成后测量值的患者。还评估了手术中提取的手术标本的肿瘤坏死百分比（TN）。

结果

纳入了1995年至2015年的84份病历。研究患者中AP和LDH均下降，CT前值高于CT后值。LHD平均下降272.95 U/L，AP平均下降10.17 U/L。平均肿瘤坏死率为65.12%。血清水平与肿瘤坏死百分比之间无统计学相关性。

结论

AP和LDH的血清水平值不是ES患者化疗诱导坏死的预测指标。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d75/5035691/6f475545f2c1/1413-7852-aob-24-04-00196-gf6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d75/5035691/65299e268ad1/1413-7852-aob-24-04-00196-gf1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d75/5035691/acdb5bbcc51f/1413-7852-aob-24-04-00196-gf2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d75/5035691/e5f212110761/1413-7852-aob-24-04-00196-gf3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d75/5035691/a38ee729b8bf/1413-7852-aob-24-04-00196-gf4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d75/5035691/c27f36e1eae7/1413-7852-aob-24-04-00196-gf5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d75/5035691/6f475545f2c1/1413-7852-aob-24-04-00196-gf6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d75/5035691/65299e268ad1/1413-7852-aob-24-04-00196-gf1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d75/5035691/acdb5bbcc51f/1413-7852-aob-24-04-00196-gf2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d75/5035691/e5f212110761/1413-7852-aob-24-04-00196-gf3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d75/5035691/a38ee729b8bf/1413-7852-aob-24-04-00196-gf4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d75/5035691/c27f36e1eae7/1413-7852-aob-24-04-00196-gf5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d75/5035691/6f475545f2c1/1413-7852-aob-24-04-00196-gf6.jpg

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