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在法医应用中,需要多少单核苷酸多态性(SNP)来取代短串联重复序列(STR)?

How many single nucleotide polymorphisms (SNPs) are needed to replace short tandem repeats (STRs) in forensic applications?

作者信息

Lee Hyo-Jung, Lee Jae Won, Jeong Su Jin, Park Mira

机构信息

Product Development HQ, DonaA-ST, 64, Cheonho-daero, Dondaemun-gu, Seoul, South Korea.

Department of Statistics, Korea University, 145, Anam-ro, Sungbuk-gu, Seoul, South Korea.

出版信息

Int J Legal Med. 2017 Sep;131(5):1203-1210. doi: 10.1007/s00414-017-1564-z. Epub 2017 Feb 27.

Abstract

Short tandem repeats (STRs) are the most commonly used forms of genetic information in forensic identification. In recent times, advances in the information on single nucleotide polymorphisms (SNPs) have raised the possibility that these markers could replace the forensically established STRs. In this work, we conducted comparative simulation studies that allowed us to estimate the number of SNPs needed if these markers were used instead of STRs in criminal cases and paternity investigations.

摘要

短串联重复序列(STRs)是法医鉴定中最常用的遗传信息形式。近年来,单核苷酸多态性(SNPs)信息的进展增加了这些标记物可能取代法医鉴定中已确立的STRs的可能性。在这项工作中,我们进行了比较模拟研究,使我们能够估计在刑事案件和亲子鉴定调查中,如果使用这些标记物而非STRs,所需的SNP数量。

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