前列腺癌患者全血样本中新型AR-V7检测：并非看上去那么简单。 - Suppr

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超能文献

Novel AR-V7 detection in whole blood samples in patients with prostate cancer: not as simple as it seems.

作者信息

Bernemann Christof, Steinestel Julie, Boegemann Martin, Schrader Andres J

机构信息

Clinic of Urology, University Hospital, Muenster, Germany.

出版信息

World J Urol. 2017 Oct;35(10):1625-1627. doi: 10.1007/s00345-017-2024-6. Epub 2017 Feb 28.

DOI:10.1007/s00345-017-2024-6

PMID:28243791

Abstract

摘要

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Novel AR-V7 detection in whole blood samples in patients with prostate cancer: not as simple as it seems.前列腺癌患者全血样本中新型AR-V7检测：并非看上去那么简单。

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Prostate cancer: AR-V7 status in CTCs is a treatment-specific biomarker.前列腺癌：循环肿瘤细胞中的AR-V7状态是一种治疗特异性生物标志物。

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AR-V7 expression in circulating tumor cells as a potential prognostic marker in metastatic hormone-sensitive prostate cancer.循环肿瘤细胞中的AR-V7表达作为转移性激素敏感性前列腺癌的潜在预后标志物。

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Detection of AR-V7 in Liquid Biopsies of Castrate Resistant Prostate Cancer Patients: A Comparison of AR-V7 Analysis in Circulating Tumor Cells, Circulating Tumor RNA and Exosomes.检测去势抵抗性前列腺癌患者的液体活检中的 AR-V7：循环肿瘤细胞、循环肿瘤 RNA 和外泌体中 AR-V7 分析的比较。

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A Whole Blood Assay for AR-V7 and AR in Patients with Prostate Cancer.用于前列腺癌患者的全血 AR-V7 和 AR 检测。

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[AR-V7 as a predictive biomarker for prostate cancer-more than just prophecy].[AR-V7作为前列腺癌的预测生物标志物——不止于预测]

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Branched Chain RNA In Situ Hybridization for Androgen Receptor Splice Variant AR-V7 as a Prognostic Biomarker for Metastatic Castration-Sensitive Prostate Cancer.雄激素受体剪接变异体 AR-V7 的分支链 RNA 原位杂交作为转移性去势敏感性前列腺癌的预后生物标志物。

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Comprehensive Profiling of the Androgen Receptor in Liquid Biopsies from Castration-resistant Prostate Cancer Reveals Novel Intra-AR Structural Variation and Splice Variant Expression Patterns.液体活检中雄激素受体的综合分析揭示了去势抵抗性前列腺癌中的新型 AR 结构变异和剪接变异表达模式。

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引用本文的文献

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Role of Androgen Receptor Variants in Prostate Cancer: Report from the 2017 Mission Androgen Receptor Variants Meeting.雄激素受体变异在前列腺癌中的作用：来自 2017 年雄激素受体变异会议的报告。

Eur Urol. 2018 May;73(5):715-723. doi: 10.1016/j.eururo.2017.11.038. Epub 2017 Dec 16.

本文引用的文献

The Detection of Androgen Receptor Splice Variant 7 in Plasma-derived Exosomal RNA Strongly Predicts Resistance to Hormonal Therapy in Metastatic Prostate Cancer Patients.血浆衍生外泌体 RNA 中雄激素受体剪接变体 7 的检测强烈预测转移性前列腺癌患者对激素治疗的耐药性。

Eur Urol. 2017 Apr;71(4):680-687. doi: 10.1016/j.eururo.2016.08.012. Epub 2016 Oct 10.

Blood Based Detection of Androgen Receptor Splice Variants in Patients with Advanced Prostate Cancer.晚期前列腺癌患者血液中雄激素受体剪接变体的检测

J Urol. 2016 Dec;196(6):1606-1607. doi: 10.1016/j.juro.2016.09.001. Epub 2016 Sep 9.

Droplet Digital PCR Based Androgen Receptor Variant 7 (AR-V7) Detection from Prostate Cancer Patient Blood Biopsies.基于液滴数字PCR的前列腺癌患者血液活检中雄激素受体变体7（AR-V7）检测

Int J Mol Sci. 2016 Aug 4;17(8):1264. doi: 10.3390/ijms17081264.

Association of AR-V7 and Prostate-Specific Antigen RNA Levels in Blood with Efficacy of Abiraterone Acetate and Enzalutamide Treatment in Men with Prostate Cancer.血液中AR-V7与前列腺特异性抗原RNA水平与醋酸阿比特龙和恩杂鲁胺治疗前列腺癌男性疗效的关联

Clin Cancer Res. 2017 Feb 1;23(3):726-734. doi: 10.1158/1078-0432.CCR-16-1070. Epub 2016 Aug 3.

A Whole Blood Assay for AR-V7 and AR in Patients with Prostate Cancer.用于前列腺癌患者的全血 AR-V7 和 AR 检测。

J Urol. 2016 Dec;196(6):1758-1763. doi: 10.1016/j.juro.2016.06.095. Epub 2016 Jul 20.

AR-V7 Transcripts in Whole Blood RNA of Patients with Metastatic Castration Resistant Prostate Cancer Correlate with Response to Abiraterone Acetate.转移性去势抵抗性前列腺癌患者全血 RNA 中的 AR-V7 转录本与醋酸阿比特龙的反应相关。

J Urol. 2017 Jan;197(1):135-142. doi: 10.1016/j.juro.2016.06.094. Epub 2016 Jul 17.

Liquid biopsy: ready to guide therapy in advanced prostate cancer?液体活检：准备好用于指导晚期前列腺癌的治疗了吗？

BJU Int. 2016 Dec;118(6):855-863. doi: 10.1111/bju.13586. Epub 2016 Aug 19.

Association of AR-V7 on Circulating Tumor Cells as a Treatment-Specific Biomarker With Outcomes and Survival in Castration-Resistant Prostate Cancer.循环肿瘤细胞上的AR-V7作为去势抵抗性前列腺癌治疗特异性生物标志物与治疗结果及生存的相关性

JAMA Oncol. 2016 Nov 1;2(11):1441-1449. doi: 10.1001/jamaoncol.2016.1828.

Analytic Validation of RNA In Situ Hybridization (RISH) for AR and AR-V7 Expression in Human Prostate Cancer.用于检测人前列腺癌中雄激素受体（AR）和AR-V7表达的RNA原位杂交（RISH）分析验证

Clin Cancer Res. 2016 Sep 15;22(18):4651-63. doi: 10.1158/1078-0432.CCR-16-0205. Epub 2016 May 10.

Detection of AR-V7 mRNA in whole blood may not predict the effectiveness of novel endocrine drugs for castration-resistant prostate cancer.检测全血中的AR-V7 mRNA可能无法预测新型内分泌药物治疗去势抵抗性前列腺癌的疗效。

Res Rep Urol. 2016 Jan 28;8:21-5. doi: 10.2147/RRU.S98877. eCollection 2016.

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