Arrigoni Francesco, Barile Antonio, Zugaro Luigi, Splendiani Alessandra, Di Cesare Ernesto, Caranci Ferdinando, Ierardi Anna Maria, Floridi Chiara, Angileri Alessio Salvatore, Reginelli Alfonso, Brunese Luca, Masciocchi Carlo
Diagnostic and Interventional Radiology, Department of Applied Clinical Science and Biotechnology, University of L'Aquila, L'Aquila, Italy.
Department of Medicine and Health Science "V. Tiberio", University of Molise, Campobasso, Italy.
Med Oncol. 2017 Apr;34(4):55. doi: 10.1007/s12032-017-0904-7. Epub 2017 Feb 27.
Purpose of this study was to evaluate the employment of MRI-guided Focused Ultrasound (MRgFUS) for treatment of intra-articular benign bone lesions as alternative to surgery, and to monitor the success of the treatment on CT and MRI images. From March 2011 to August 2013, 14 intra-articular benign bone lesions were treated with MRgFUS. All patients were studied by CT and MR imaging. Pain was measured using the visual analogue scale (VAS) before and after treatment (6 and 12 months). All patients in our series demonstrated regression in painful symptomatology during screening. A significant drop in the mean VAS pain score (from 7.8 to 0.6) was observed at 12-month follow-up, and pain medication was no longer needed after treatment. No complications were observed. Three diagnostic imaging signs were found suggesting absence of biological activity and confirming the clinical findings: calcification of the treated lesion, lack of contrast enhancement and disappearance of bone oedema around the lesions.
the employment of MRgFUS is safe and effective in the treatment of intra-articular benign bone lesions. The clinical outcome is satisfactory, and the success of the treatment is confirmed by diagnostic imaging.
本研究的目的是评估磁共振成像引导聚焦超声（MRgFUS）用于治疗关节内良性骨病变以替代手术的可行性，并通过CT和MRI图像监测治疗效果。2011年3月至2013年8月，14例关节内良性骨病变患者接受了MRgFUS治疗。所有患者均接受了CT和MR成像检查。治疗前及治疗后6个月和12个月使用视觉模拟量表（VAS）测量疼痛程度。本系列所有患者在筛查期间疼痛症状均有减轻。在12个月的随访中，平均VAS疼痛评分显著下降（从7.8降至0.6），治疗后不再需要止痛药物。未观察到并发症。发现三个诊断性影像学征象提示病变无生物学活性并证实了临床结果：治疗病变的钙化、无对比增强以及病变周围骨水肿消失。
MRgFUS用于治疗关节内良性骨病变安全有效。临床结果令人满意，诊断性影像学证实了治疗效果。
