Hajek A, Luck T, Brettschneider C, Posselt T, Lange C, Wiese B, Steinmann S, Weyerer S, Werle J, Pentzek M, Fuchs A, Stein J, Bickel H, Mösch E, Wagner M, Heser K, Maier W, Scherer J M, Riedel-Heller S G, König H-H
Dr. André Hajek, University Medical Center, Hamburg-Eppendorf, Hamburg Center for Health Economics, Department of Health Economics and Health Services Research, Telephone +49 40 7410 52877; Fax +49 40 7410 40261, E-mail:
J Nutr Health Aging. 2017;21(3):299-306. doi: 10.1007/s12603-016-0771-5.
To investigate causal factors of functional impairment in old age in a longitudinal approach.
A population-based prospective cohort study.
Elderly individuals were recruited via GP offices at six study centers in Germany. They were observed every 1.5 years over six waves.
Three thousand two hundred fifty-six people aged 75 years and older at baseline.
Functional impairment was quantified by the Lawton and Brody Instrumental Activities of Daily Living scale (IADL) and the Barthel-Index (BI).
Fixed effects regressions revealed that functional impairment (IADL; BI) increased significantly with ageing (β=-.2; β=-1.1), loss of a spouse (β= .5; β=-3.1), not living alone in private household (β=-1.2; β=-5.5), depression (solely significant for IADL: β= .6) and dementia (β=-2.3; β=-18.2). The comorbidity score did not affect functional impairment.
Our findings underline the relevance of changes in sociodemographic variables as well as the occurrence of depression or dementia for functional impairment. While several of these causal factors for functional decline in the oldest old are inevitable, some may not be, such as depression. Therefore, developing interventional strategies to prevent depression might be a fruitful approach in order to delay functional impairment in old age.
采用纵向研究方法探讨老年功能障碍的因果因素。
基于人群的前瞻性队列研究。
通过德国六个研究中心的全科医生办公室招募老年人。对他们进行了六轮观察,每1.5年观察一次。
基线时3256名75岁及以上的老年人。
功能障碍通过劳顿和布罗迪日常生活能力量表(IADL)和巴氏指数(BI)进行量化。
固定效应回归显示,功能障碍(IADL;BI)随着年龄增长(β = -0.2;β = -1.1)、配偶去世(β = 0.5;β = -3.1)、不住在私人家庭单独居住(β = -1.2;β = -5.5)、抑郁(仅对IADL有显著影响:β = 0.6)和痴呆(β = -2.3;β = -18.2)而显著增加。合并症评分不影响功能障碍。
我们的研究结果强调了社会人口统计学变量变化以及抑郁或痴呆的发生与功能障碍的相关性。虽然这些导致最年长者功能衰退的因果因素中有几个是不可避免的,但有些可能并非如此,比如抑郁。因此,制定预防抑郁的干预策略可能是延缓老年功能障碍的有效方法。