Laboratory of Neuroepigenetics, Medical Faculty of the University of Zürich and Department of Health Sciences and Technology of the ETH Zürich, Brain Research Institute, Neuroscience Center Zürich, Zürich, Switzerland.
Nat Methods. 2017 Feb 28;14(3):243-249. doi: 10.1038/nmeth.4181.
Recent work has demonstrated that environmental factors experienced by parents can affect their offspring across multiple generations, and that such transgenerational transmission can depend on the germline. Causal evidence for the involvement of germ cells is rare, however, and the underlying molecular mechanisms remain poorly understood. Further, studies often employ varying methods in experimental design and data interpretation. We provide a critical analysis of these issues and suggest possible solutions and guidelines for improving study design and generating reproducible and high-quality data.
最近的研究表明，父母经历的环境因素可以在多个世代中影响他们的后代，并且这种跨代传递可能依赖于生殖系。然而，涉及生殖细胞的因果证据很少，并且潜在的分子机制仍知之甚少。此外，研究通常在实验设计和数据解释中采用不同的方法。我们对这些问题进行了批判性分析，并提出了可能的解决方案和指导方针，以改善研究设计并生成可重复和高质量的数据。
