Kaji E, Bornslaeger E A, Schultz R M
Department of Biology, University of Pennsylvania, Philadelphia 19104.
J Exp Zool. 1987 Sep;243(3):489-93. doi: 10.1002/jez.1402430316.
Testosterone, progesterone, and estradiol-17 beta each inhibit cAMP phosphodiesterase activity of mouse oocyte extracts in a concentration-dependent manner. This finding provides an explanation for the inhibitory effect of steroid hormones on germinal vesicle breakdown (GVBD) of mouse oocytes in vitro. Furthermore, it raises the possibility that steroid hormones present in follicular fluid participate in maintaining meiotic arrest in vivo by acting in a nonclassical manner.
睾酮、孕酮和雌二醇 - 17β均以浓度依赖性方式抑制小鼠卵母细胞提取物的环磷酸腺苷磷酸二酯酶活性。这一发现为类固醇激素在体外对小鼠卵母细胞生发泡破裂（GVBD）的抑制作用提供了解释。此外，这也增加了卵泡液中存在的类固醇激素通过非经典方式作用来维持体内减数分裂停滞的可能性。
