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[心脏性猝死中心脏与大脑的相互作用]

[Interaction between heart and brain in sudden cardiac death].

作者信息

Fatar M, Akin I, Borggrefe M, Platten M, Alonso A

机构信息

Neurologische Klinik, Universitätsmedizin Mannheim, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Deutschland.

I. Medizinische Klinik/Kardiologie, Universitätsmedizin Mannheim, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Deutschland.

出版信息

Herz. 2017 Apr;42(2):171-175. doi: 10.1007/s00059-017-4547-4.

Abstract

The heart and brain are constantly interacting under normal physiological conditions. This interaction is under the control of the autonomic nervous system with parasympathetic and sympathetic nerve fibers including the participating brain structures. Pathological conditions, such as epilepsy and ischemic cerebral stroke influence heart function, especially the frequency and may result in severe arrhythmia. An asymmetric influence of the left and right brain hemispheres on the heart rate is still under debate. Conversely, the influence of the heart in cases of acute cardiac arrest on brain function is equally relevant and a common clinical problem after resuscitation. We review the damaging cascade of global cerebral hypoxia and the value of different diagnostic procedures as well as the ethical problem of the point in time of termination of consciousness and the instruments for estimating the prognosis.

摘要

在正常生理条件下,心脏和大脑不断相互作用。这种相互作用受自主神经系统控制,包括副交感神经纤维和交感神经纤维以及参与其中的脑结构。癫痫和缺血性脑卒中等病理状况会影响心脏功能,尤其是心率,可能导致严重心律失常。左右脑半球对心率的不对称影响仍存在争议。相反,急性心脏骤停时心脏对脑功能的影响同样重要,是复苏后常见的临床问题。我们综述了全脑缺氧的损伤级联反应、不同诊断程序的价值以及意识终止时间的伦理问题和预后评估手段。

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