• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Nerve growth factor is a neurotrophic factor for forebrain cholinergic neurons; implications for Alzheimer's disease.

作者信息

Hefti F, Will B

机构信息

Department of Neurology, University of Miami School of Medicine, Florida.

出版信息

J Neural Transm Suppl. 1987;24:309-15.

PMID:2824691
Abstract

Findings obtained in recent years provide strong evidence that nerve growth factor (NGF) acts as a neurotrophic factor for cholinergic neurons of the mammalian forebrain. NFG receptors are exclusively localized on these neurons in the rat and human forebrain. NGF promotes survival, fiber elongation and expression of transmitter-specific enzymes of forebrain cholinergic neurons, in vivo and in vitro. In adult rats, intraventricular injections of NGF attenuate the degeneration of these cells after experimental lesions. These findings suggest that NGF might be able to attenuate the degeneration of cholinergic neurons occurring in Alzheimer's disease.

摘要

相似文献

1
Nerve growth factor is a neurotrophic factor for forebrain cholinergic neurons; implications for Alzheimer's disease.
J Neural Transm Suppl. 1987;24:309-15.
2
Nerve growth factor and Alzheimer's disease.神经生长因子与阿尔茨海默病
Ann Neurol. 1986 Sep;20(3):275-81. doi: 10.1002/ana.410200302.
3
Development of cholinergic pedunculopontine neurons in vitro: comparison with cholinergic septal cells and response to nerve growth factor, ciliary neuronotrophic factor, and retinoic acid.体外胆碱能脑桥脚被盖神经元的发育：与胆碱能隔区细胞的比较以及对神经生长因子、睫状神经营养因子和视黄酸的反应
J Neurosci Res. 1988 Oct-Dec;21(2-4):365-75. doi: 10.1002/jnr.490210228.
4
Direct, complex effects of estrogens on basal forebrain cholinergic neurons.雌激素对基底前脑胆碱能神经元的直接、复杂影响。
Exp Neurol. 2005 Aug;194(2):506-22. doi: 10.1016/j.expneurol.2005.03.015.
5
Differential modulation of the cholinergic phenotype of the nucleus basalis magnocellularis neurons by applying NGF at the cell body or cortical terminal fields.通过在细胞体或皮质终末场施加神经生长因子对基底大细胞核神经元胆碱能表型进行差异性调节。
Exp Neurol. 1997 Jan;143(1):162-71. doi: 10.1006/exnr.1996.6357.
6
Role of nerve growth factor in the expression of trkA mRNA in cultured embryonic rat basal forebrain cholinergic neurons.神经生长因子在培养的胚胎大鼠基底前脑胆碱能神经元中trkA mRNA表达中的作用。
J Neurosci Res. 1995 Dec 15;42(6):775-83. doi: 10.1002/jnr.490420606.
7
Impairment of basal forebrain cholinergic neurons associated with aging and long-term loss of ovarian function.与衰老及卵巢功能长期丧失相关的基底前脑胆碱能神经元损伤。
Exp Neurol. 1998 Jun;151(2):289-302. doi: 10.1006/exnr.1998.6789.
8
Comparison of nerve growth factor's effects on development of septum, striatum, and nucleus basalis cholinergic neurons in vitro.神经生长因子对体外培养的隔区、纹状体及基底核胆碱能神经元发育影响的比较。
J Neurosci Res. 1988 Oct-Dec;21(2-4):352-64. doi: 10.1002/jnr.490210227.
9
Highly selective effects of nerve growth factor, brain-derived neurotrophic factor, and neurotrophin-3 on intact and injured basal forebrain magnocellular neurons.神经生长因子、脑源性神经营养因子和神经营养素-3对完整和损伤的基底前脑大细胞神经元的高度选择性作用。
J Comp Neurol. 1994 May 8;343(2):247-62. doi: 10.1002/cne.903430206.
10
Decreased TrkA gene expression in cholinergic neurons of the striatum and basal forebrain of patients with Alzheimer's disease.阿尔茨海默病患者纹状体和基底前脑胆碱能神经元中TrkA基因表达降低。
Exp Neurol. 1997 May;145(1):245-52. doi: 10.1006/exnr.1997.6443.

引用本文的文献

1
Three-dimensional organotypic mouse brain slices to study Alzheimer's disease pathologies: a review.用于研究阿尔茨海默病病理学的三维器官型小鼠脑切片：综述
Front Dement. 2025 Jul 25;4:1585124. doi: 10.3389/frdem.2025.1585124. eCollection 2025.
2
Multimodal beneficial effects of BNN27, a nerve growth factor synthetic mimetic, in the 5xFAD mouse model of Alzheimer's disease.神经生长因子合成模拟物BNN27在阿尔茨海默病5xFAD小鼠模型中的多模态有益作用。
Mol Psychiatry. 2025 Jun;30(6):2265-2283. doi: 10.1038/s41380-024-02833-w. Epub 2024 Nov 25.
3
Nerve Growth Factor Compromise in Down Syndrome.
唐氏综合征中的神经生长因子受损
Front Aging Neurosci. 2021 Aug 9;13:719507. doi: 10.3389/fnagi.2021.719507. eCollection 2021.
4
Neurotrophic Factors and Their Potential Applications in Tissue Regeneration.神经营养因子及其在组织再生中的潜在应用。
Arch Immunol Ther Exp (Warsz). 2016 Apr;64(2):89-99. doi: 10.1007/s00005-015-0376-4. Epub 2015 Nov 26.
5
GABAergic terminals are a source of galanin to modulate cholinergic neuron development in the neonatal forebrain.γ-氨基丁酸能终末是甘丙肽的一个来源，可调节新生前脑胆碱能神经元的发育。
Cereb Cortex. 2014 Dec;24(12):3277-88. doi: 10.1093/cercor/bht192. Epub 2013 Jul 29.
6
Nerve growth factor scales endocannabinoid signaling by regulating monoacylglycerol lipase turnover in developing cholinergic neurons.神经生长因子通过调节发育中胆碱能神经元中单酰基甘油脂肪酶的周转来调节内源性大麻素信号转导。
Proc Natl Acad Sci U S A. 2013 Jan 29;110(5):1935-40. doi: 10.1073/pnas.1212563110. Epub 2013 Jan 14.
7
Expressions of Axl and Tyro-3 receptors are under regulation of nerve growth factor and are involved in differentiation of PC12 cells.Axl 和 Tyro-3 受体的表达受神经生长因子的调节，参与 PC12 细胞的分化。
Neurosci Bull. 2011 Feb;27(1):15-22. doi: 10.1007/s12264-011-1042-4.
8
Advances in the pharmacotherapy of Alzheimer's disease.阿尔茨海默病药物治疗的进展
Eur Arch Psychiatry Clin Neurosci. 1994;244(5):261-71. doi: 10.1007/BF02190379.
9
Neurite extension and neuronal survival activities of recombinant S100 beta proteins that differ in the content and position of cysteine residues.半胱氨酸残基的含量和位置不同的重组S100β蛋白的神经突延伸和神经元存活活性。
J Cell Biol. 1989 Dec;109(6 Pt 1):3063-71. doi: 10.1083/jcb.109.6.3063.