饮食与生理对生殖系干细胞谱系的调控
Control of Germline Stem Cell Lineages by Diet and Physiology.
作者信息
Laws Kaitlin M, Drummond-Barbosa Daniela
机构信息
Department of Biochemistry and Molecular Biology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, 21205, USA.
Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, 21205, USA.
出版信息
Results Probl Cell Differ. 2017;59:67-99. doi: 10.1007/978-3-319-44820-6_3.
Tight coupling of reproduction to environmental factors and physiological status is key to long-term species survival. In particular, highly conserved pathways modulate germline stem cell lineages according to nutrient availability. This chapter focuses on recent in vivo studies in genetic model organisms that shed light on how diet-dependent signals control the proliferation, maintenance, and survival of adult germline stem cells and their progeny. These signaling pathways can operate intrinsically in the germ line, modulate the niche, or act through intermediate organs to influence stem cells and their differentiating progeny. In addition to illustrating the extent of dietary regulation of reproduction, findings from these studies have implications for fertility during aging or disease states.
繁殖与环境因素及生理状态的紧密耦合是物种长期生存的关键。特别是，高度保守的信号通路会根据营养物质的可利用性来调节生殖系干细胞谱系。本章重点介绍了在遗传模式生物中进行的最新体内研究，这些研究揭示了饮食依赖性信号如何控制成体生殖系干细胞及其后代的增殖、维持和存活。这些信号通路可在生殖系中内在发挥作用、调节干细胞微环境，或通过中间器官来影响干细胞及其分化中的后代。除了阐明饮食对生殖的调节程度外，这些研究的结果还对衰老或疾病状态下的生育能力具有启示意义。
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