挪威 1 型糖尿病合并乳糜泻患者的 HLA Ⅱ类等位基因。
HLA class II alleles in Norwegian patients with coexisting type 1 diabetes and celiac disease.
机构信息
Department of Immunology, Oslo University Hospital and University of Oslo, Oslo, Norway.
Department of Medical Genetics, University of Oslo and Oslo University Hospital, Oslo, Norway.
出版信息
HLA. 2017 May;89(5):278-284. doi: 10.1111/tan.12986. Epub 2017 Feb 28.
BACKGROUND
Type 1 diabetes (T1D) and celiac disease (CeD) are 2 distinct diseases, but there is an increased risk of developing CeD for T1D patients. Both diseases are associated with HLA-class II alleles, such as DQB1 *02:01 and DQB1 *03:02; however, their risk contribution vary between the diseases.
MATERIALS AND METHODS
We genotyped HLA-DRB1 and - DQB1 in 215 patients with coexisting T1D and CeD identified from a T1D cohort, and compared them to patients with T1D (N = 487) and CeD (N = 327), as well as healthy controls (N = 368).
RESULTS
The patients with coexisting T1D and CeD had an intermediate carrier frequency (72.8%) of the DRB1 *03:01- DQB1 *02:01- DQA1 *05:01 haplotype compared to T1D (64.1%) and CeD (88.7%) patients. The DRB1 *03:01- DQB1 *02:01- DQA1 *05:01/ DRB1 *04- DQB1 *03:02- DQA1 *03 haplotype combination, encoding DQ2.5 and DQ8 molecules, was equally frequent among patients with both T1D and CeD (52.6%) and T1D patients (46.8%) but significantly lower in CeD patients (9.5%).
CONCLUSION
Overall, the patients with coexisting T1D and CeD had an HLA profile more similar to T1D patients than CeD patients.
背景
1 型糖尿病（T1D）和乳糜泻（CeD）是两种截然不同的疾病，但 T1D 患者患 CeD 的风险增加。这两种疾病都与 HLA-Ⅱ类等位基因有关，如 DQB102:01 和 DQB103:02；然而，它们的风险贡献在两种疾病之间有所不同。
材料和方法
我们对来自 T1D 队列中确诊的 215 例同时患有 T1D 和 CeD 的患者进行了 HLA-DRB1 和-DQB1 基因分型，并与 T1D 患者（N=487）、CeD 患者（N=327）和健康对照者（N=368）进行了比较。
结果
与 T1D（64.1%）和 CeD（88.7%）患者相比，同时患有 T1D 和 CeD 的患者携带 DRB103:01-DQB102:01-DQA105:01 单体型的频率居中（72.8%）。DRB103:01-DQB102:01-DQA105:01/DRB104-DQB103:02-DQA1*03 单体型组合在同时患有 T1D 和 CeD 的患者（52.6%）和 T1D 患者（46.8%）中同样常见，但在 CeD 患者中明显较低（9.5%）。
结论
总的来说，同时患有 T1D 和 CeD 的患者的 HLA 表型与 T1D 患者更为相似，而与 CeD 患者不同。
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