Kogan M I, Belousov I I, Ibishev H S, Vorobyev S V, Khripun I A, Sizyakin D V, Cherniy A A, Morgunov M N, Paleniy A V
Department of Urology and Human Reproductive Health with the Course of Pediatric Urology-Andrology, FPE of Rostov State Medical University.
Department of Endocrinology with the Course of Pediatric Endocrinology, FPE of the Rostov State Medical University.
Urologiia. 2015 Dec(6):87-92.
The current literature is lacking sufficient coverage of the relationship between erectile dysfunction (ED) and diabetes mellitus (DM), and age-related hypogonadism. At the same time, the mutual impact of cardiovascular and endocrine systems on men erectile function and the resulting damage of male sexual organs are being studied and debated. This prospective, randomized, simple comparative study examined the erectile function of 131 men with type 2 DM and age-related hypogonadism, tested the effects of DM on serum testosterone, formed an idea of possible relationship between DM, severity of ED and testosterone levels, degree of endothelial dysfunction and the involvement of the testicles. The study results showed the impact of testosterone level on the compensation of DM and frequency of ED. Correlations were observed between testosterone levels, peak systolic velocity of blood flow in the of capsular arteries of testes and testicular size. The interrelation between testicular size, reduction of testicular blood flow, and DM-related endothelial dysfunction and variability of serum testosterone levels was found. The findings suggest the need for revising existing reference ranges for serum testosterone upward to 15 nmol/L.
目前的文献对勃起功能障碍（ED）与糖尿病（DM）以及年龄相关性性腺功能减退之间的关系缺乏足够的阐述。与此同时，心血管系统和内分泌系统对男性勃起功能的相互影响以及由此导致的男性性器官损害正在被研究和讨论。这项前瞻性、随机、简单对比研究对131名患有2型糖尿病和年龄相关性性腺功能减退的男性的勃起功能进行了检查，测试了糖尿病对血清睾酮的影响，形成了关于糖尿病、勃起功能障碍严重程度与睾酮水平、内皮功能障碍程度以及睾丸受累之间可能关系的概念。研究结果显示了睾酮水平对糖尿病代偿和勃起功能障碍发生率的影响。观察到睾酮水平、睾丸包膜动脉血流收缩期峰值速度与睾丸大小之间存在相关性。发现了睾丸大小、睾丸血流减少、与糖尿病相关的内皮功能障碍以及血清睾酮水平变化之间的相互关系。研究结果表明有必要将现有的血清睾酮参考范围向上修订至15 nmol/L。
