Tyumentseva N V, Yushkov B G, Medvedeva S Y, Kovalenko R Y, Uzbekov O K, Zhuravlev V N
Institute of Immunology and Physiology, Ural Branch of RAS, Ekaterinburg.
Institute of Medical Cell Technologies, Ekaterinburg.
Urologiia. 2016 Dec(6):60-64.
Experiments on laboratory rats have shown the feasibility of autoplastic repair of urinary bladder wall defects using a connective-tissue capsule formed as the result of an inflammatory response to the presence of a foreign body. The formation of connective tissue prosthesis is characterized by developing fibrous connective tissue, ordering of collagen fibers, reducing the number of cells per unit area with a predominance of more mature cells - fibroblasts. With increasing time of observation, connective tissue prostheses were found to acquire a morphological structure similar to that of the urinary bladder wall. By month 12, the mucosa, the longitudinal and circular muscle layers were formed. The proposed method of partial autoplastic repair of urinary bladder wall is promising, has good long-term results, but requires further experimental studies.
对实验大鼠的实验表明，利用因对异物存在产生炎症反应而形成的结缔组织囊进行膀胱壁缺损的自身组织修复是可行的。结缔组织假体的形成特点是发展出纤维结缔组织、胶原纤维有序排列、单位面积内细胞数量减少且以更成熟的细胞——成纤维细胞为主。随着观察时间的增加，发现结缔组织假体获得了与膀胱壁相似的形态结构。到第12个月时，形成了黏膜、纵肌层和环肌层。所提出的膀胱壁部分自身组织修复方法具有前景，长期效果良好，但需要进一步的实验研究。
