Yoshida Y, Tsuji S, Mori M, Satoh M, Kamijo K, Yabana T, Yachi A, Imamura M
Dept. of Pathology, Hokkaido Children's Hospital & Medical Center.
Gan No Rinsho. 1987 Oct;33(12):1446-52.
A tissue specimen taken from the pancreatic tumor of a patient suffering from Zollinger-Ellison syndrome associated with a concurrent Cushing's syndrome was investigated both morphologically and immunohistochemically. Histologically, the tumor cells were found to be arranged in a cord or ribbon pattern. An immunohistochemical study revealed that the tumor nodule contained both gastrin and ACTH. Further, double stainings of the same section disclosed that the same tumor nodule possessed both hormones simultaneously, thus confirming the concurrent presence of Zollinger-Ellison syndrome and Cushing's syndrome. An electron micrograph of the tumor cell showed the presence of numerous endocrine-type granules in the cytoplasm. These findings substantiate the concurrent presence of the two characteristic clinical syndromes.
对一名患有佐林格-埃利森综合征并伴有库欣综合征的患者的胰腺肿瘤组织标本进行了形态学和免疫组织化学研究。组织学上，肿瘤细胞呈条索状或带状排列。免疫组织化学研究显示，肿瘤结节中同时含有胃泌素和促肾上腺皮质激素。此外，对同一切片进行双重染色发现，同一肿瘤结节同时含有这两种激素，从而证实了佐林格-埃利森综合征和库欣综合征同时存在。肿瘤细胞的电子显微镜照片显示细胞质中存在大量内分泌型颗粒。这些发现证实了这两种特征性临床综合征的同时存在。
