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髋关节假体周围感染处理中的清创与植入物保留:单中心引导式快速治疗后的结果

Debridement and implant retention in the management of hip periprosthetic joint infection: outcomes following guided and rapid treatment at a single centre.

作者信息

Sendi P, Lötscher P O, Kessler B, Graber P, Zimmerli W, Clauss M

机构信息

Kantonsspital Baselland, Rheinstrasse 26, 4410 Liestal, Switzerland.

出版信息

Bone Joint J. 2017 Mar;99-B(3):330-336. doi: 10.1302/0301-620X.99B3.BJJ-2016-0609.R1.

DOI:10.1302/0301-620X.99B3.BJJ-2016-0609.R1
PMID:28249972
Abstract

AIMS

To analyse the effectiveness of debridement and implant retention (DAIR) in patients with hip periprosthetic joint infection (PJI) and the relationship to patient characteristics. The outcome was evaluated in hips with confirmed PJI and a follow-up of not less than two years.

PATIENTS AND METHODS

Patients in whom DAIR was performed were identified from our hip arthroplasty register (between 2004 and 2013). Adherence to criteria for DAIR was assessed according to a previously published algorithm.

RESULTS

DAIR was performed as part of a curative procedure in 46 hips in 42 patients. The mean age was 73.2 years (44.6 to 87.7), including 20 women and 22 men. In 34 hips in 32 patients (73.9%), PJI was confirmed. In 12 hips, the criteria for PJI were not fulfilled and antibiotics stopped. In 41 (89.1%) of all hips and in 32 (94.1%) of the confirmed PJIs, all criteria for DAIR were fulfilled. In patients with exogenous PJI, DAIR was performed not more than three days after referral. In haematogenous infections, the duration of symptoms did not exceed 21 days. In 28 hips, a single debridement and in six hips two surgical debridements were required. In 28 (87.5%) of 32 patients, the total treatment duration was three months. Failure was noted in three hips (9%). Long-term follow-up results (mean 4.0 years, 1.4 to 10) were available in 30 of 34 (88.2%) confirmed PJIs. The overall successful outcome rate was 91% in 34 hips, and 90% in 30 hips with long-term follow-up results.

CONCLUSION

Prompt surgical treatment with DAIR, following strict diagnostic and therapeutic criteria, in patients with suspected periprosthetic joint infection, can lead to high rates of success in eradicating the infection. Cite this article: 2017;99-B:330-6.

摘要

目的

分析清创及保留植入物(DAIR)治疗髋关节假体周围感染(PJI)患者的有效性及其与患者特征的关系。对确诊为PJI且随访不少于两年的髋关节进行疗效评估。

患者与方法

从我们的髋关节置换登记系统中识别出接受DAIR治疗的患者(2004年至2013年期间)。根据先前公布的算法评估是否符合DAIR标准。

结果

42例患者的46个髋关节接受了DAIR作为治疗手段的一部分。平均年龄为73.2岁(44.6至87.7岁),其中女性20例,男性22例。32例患者的34个髋关节(73.9%)确诊为PJI。12个髋关节不符合PJI标准,停用抗生素。所有髋关节中有41个(89.1%)、确诊的PJI中有32个(94.1%)符合DAIR的所有标准。对于外源性PJI患者,转诊后不超过三天即进行DAIR治疗。血源性感染患者症状持续时间不超过21天。28个髋关节需要单次清创,6个髋关节需要两次手术清创。32例患者中有28例(87.5%)总治疗时间为三个月。3个髋关节(9%)治疗失败。34例确诊的PJI中有30例(88.2%)获得长期随访结果(平均4.0年,1.4至10年)。34个髋关节的总体成功率为91%,30个有长期随访结果的髋关节成功率为90%。

结论

对于疑似假体周围关节感染的患者,严格按照诊断和治疗标准及时采用DAIR进行手术治疗,可获得较高的感染根除成功率。引用本文:2017;99-B:330-6。

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