McLean S, Rice K C, Lessor R, Rothman R B
Laboratory of Neurophysiology, NIMH, Bethesda, MD 20892.
Neuropeptides. 1987 Oct;10(3):235-9. doi: 10.1016/0143-4179(87)90073-4.
The autoradiographic distribution of [3H]cyclofoxy (6-deoxy-6 beta-fluoronaltrexone) after in vivo administration or in vitro incubation suggests that it labels mu and kappa opioid receptors. In the rat, the pattern of [3H]cyclofoxy binding is similar to the distribution of mu receptors, however labeling is also present in the neural lobe of the pituitary, the central nucleus of the amygdala and the hypothalamus, areas where kappa receptors outnumber mu receptors. In the guinea pig, [3H]cyclofoxy binding sites are dense in the deep layers of the cortex, an area enriched in kappa receptors. These results are consistent with [3H]cyclofoxy binding to mu and kappa receptors.
体内给药或体外孵育后，[3H]环福可昔（6-脱氧-6β-氟纳曲酮）的放射自显影分布表明它标记了μ和κ阿片受体。在大鼠中，[3H]环福可昔结合模式与μ受体分布相似，然而在垂体神经叶、杏仁核中央核和下丘脑（这些区域κ受体数量超过μ受体）也有标记。在豚鼠中，[3H]环福可昔结合位点在皮质深层密集，该区域富含κ受体。这些结果与[3H]环福可昔与μ和κ受体结合一致。
