Tannen R L
Division of Nephrology, University of Michigan Medical School, Ann Arbor 48109-0364.
Semin Nephrol. 1987 Sep;7(3):263-73.
In summary, altered potassium homeostasis can modify bicarbonate reabsorption by the proximal tubule and alter acidification by the distal nephron both by affecting proton transport in a primary fashion and by modifying renal ammonia production. With physiologic variations in dietary K+ intake, these processes may serve to sustain concurrent potassium and acid-base homeostasis. However, with pathologic degrees of potassium depletion and hyperkalemia, metabolic alkalosis and acidosis, respectively, can result.
总之，钾稳态的改变可通过主要影响质子转运以及改变肾脏氨的生成，来改变近端小管对碳酸氢盐的重吸收，并改变远端肾单位的酸化作用。随着饮食中钾摄入量的生理变化，这些过程可能有助于维持钾和酸碱平衡的同时稳定。然而，在钾缺乏和高钾血症的病理程度下，分别可导致代谢性碱中毒和酸中毒。
