Research School of Chemistry, The Australian National University, Canberra, ACT 2601, Australia.
School of Chemistry, The Australian Centre for Nanomedicine and the ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, The University of New South Wales, Sydney, NSW 2052, Australia.
Sci Rep. 2017 Mar 3;7:43668. doi: 10.1038/srep43668.
A peptide amphiphile is reported, that gelates a range of polar organic solvents including acetonitrile/water, N,N-dimethylformamide and acetone, in a process dictated by β-sheet interactions and facilitated by the presence of an alkyl chain. Similarities with previously reported peptide amphiphile hydrogelators indicate analogous underlying mechanisms of gelation and structure-property relationships, suggesting that peptide amphiphile organogel design may be predictably based on hydrogel precedents.
据报道，一种肽两亲分子可以在β-折叠相互作用的控制下，通过烷基链的存在促进一系列极性有机溶剂（包括乙腈/水、N,N-二甲基甲酰胺和丙酮）的凝胶化过程。与先前报道的肽两亲分子水凝胶形成剂的相似性表明了凝胶形成和结构-性能关系的类似潜在机制，这表明肽两亲分子有机凝胶的设计可以根据水凝胶的先例进行预测。
