Kooshki A, Samadipour E, Akbarzadeh R
Department of Nutrition & Biochemistry, Sabzevar University of Medical Sciences, Sabzevar, Iran.
Para Medicine School, Sabzevar University of Medical Sciences, Sabzevar, Iran.
J Med Life. 2015;8(Spec Iss 2):43-46.
Despite the high levels of inflammation in hemodialysis patients and the effects of diet on systemic inflammation, such as the development of atherosclerosis and cardiovascular disease, few studies have evaluated the relationship of macronutrients and antioxidants intake with serum C-reactive protein (CRP). Therefore, this study assessed the relationship between serum high sensitivity CRP (hs-CRP) with macronutrients and antioxidants intake and serum albumin. This cross-sectional study used census sampling to select 75 hemodialysis patients (35 men and 40 women) who attended the hemodialysis department of Vaseie Hospital of Sabzevar, Iran. After obtaining the written consent, all the patients were interviewed and dietary data was collected by using a semi-quantitative food frequency questionnaire including 160 food items. Diet analysis was performed with Nutritionist IV. Before being connected to the dialysis machine, 5 cc fasting blood samples were obtained from all participants and serum hs-CRP and albumin levels were measured. All the statistical analyses were conducted with SPSS -for Windows, version 16.0. The patients' mean body mass index was 20.09 ± 3.27 kg/ m2. The participants' intake of antioxidants and all macronutrients, except for carbohydrates and proteins, was less than the standard levels. Moreover, the hs-CRP had significant inverse relationships with serum albumin (P=0.0001) and vitamin E and C intakes but was not significant. Also, a significant relationship was observed between hs-CRP levels and the intake of energy (P=0.002) and protein (P=0.0001). Our findings indicated hs-CRP levels of hemodialysis patients to have significant inverse relationships with serum albumin and vitamin E and C intakes but was not significant. Also, a significant relationship was observed between hs-CRP levels and the intake of energy and protein.
尽管血液透析患者体内炎症水平较高，且饮食对全身炎症有影响，如动脉粥样硬化和心血管疾病的发生，但很少有研究评估常量营养素和抗氧化剂摄入量与血清C反应蛋白（CRP）之间的关系。因此，本研究评估了血清高敏CRP（hs-CRP）与常量营养素、抗氧化剂摄入量以及血清白蛋白之间的关系。这项横断面研究采用普查抽样方法，选取了伊朗萨卜泽瓦尔瓦塞伊医院血液透析科的75名血液透析患者（35名男性和40名女性）。在获得书面同意后，对所有患者进行了访谈，并使用包含160种食物的半定量食物频率问卷收集饮食数据。使用营养师IV软件进行饮食分析。在连接透析机之前, 从所有参与者身上采集了5毫升空腹血样，并测量血清hs-CRP和白蛋白水平。所有统计分析均使用SPSS for Windows 16.0版软件进行。患者的平均体重指数为20.09±3.27kg/m²。除碳水化合物和蛋白质外，参与者的抗氧化剂和所有常量营养素摄入量均低于标准水平。此外，hs-CRP与血清白蛋白（P=0.0001）以及维生素E和C的摄入量呈显著负相关，但不显著。同时，观察到hs-CRP水平与能量摄入量（P=0.002）和蛋白质摄入量（P=0.0001）之间存在显著关系。我们的研究结果表明，血液透析患者的hs-CRP水平与血清白蛋白以及维生素E和C的摄入量呈显著负相关，但不显著。同时，观察到hs-CRP水平与能量和蛋白质摄入量之间存在显著关系。
