Oberman H A
Department of Pathology, University of Michigan Medical Center, Ann Arbor 48109-0054.
Am J Surg Pathol. 1987 Dec;11(12):918-29. doi: 10.1097/00000478-198712000-00002.
The clinical and pathologic findings in 29 patients whose primary breast neoplasm manifested the microscopic pattern of spindle cell carcinoma or extensive squamous or pseudosarcomatous metaplasia were studied. In several of the tumors, the diagnosis of primary sarcoma or squamous cell carcinoma was excluded only after a prolonged search for evidence of invasive ductal carcinoma. The paucity of axillary lymph node metastases and the circumscription of these neoplasms belied their aggressive clinical behavior. The size of the neoplasm at the time of initial treatment best correlated with prognosis, since the majority of patients whose carcinoma was less than 4 cm in diameter pursued a favorable course. The lack of correlation of the microscopic pattern of these neoplasms with prognosis, as well as the presence of apparent overlapping microscopic findings, supports the concept that they are variants of a single entity.
对29例原发性乳腺肿瘤表现为梭形细胞癌或广泛鳞状或假肉瘤样化生微观模式的患者的临床和病理结果进行了研究。在一些肿瘤中，仅在长时间寻找浸润性导管癌证据后才排除原发性肉瘤或鳞状细胞癌的诊断。腋窝淋巴结转移较少以及这些肿瘤的局限性掩盖了它们侵袭性的临床行为。初始治疗时肿瘤的大小与预后最相关，因为大多数直径小于4 cm的癌患者预后良好。这些肿瘤的微观模式与预后缺乏相关性，以及明显重叠的微观发现的存在，支持了它们是单一实体变体的概念。
