硫利达嗪与双氯西林联合使用作为葡萄球菌的一种可能治疗策略。

Combination of thioridazine and dicloxacillin as a possible treatment strategy of staphylococci.

作者信息

Rasmussen Kristian Severin, Poulsen Marianne Ø, Jacobsen Kirstine, Skov Marianne N, Kolmos Hans Jørn, Kallipolitis Birgitte H, Klitgaard Janne K

机构信息

Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark.

Institute of Clinical Research, Research Unit of Clinical Microbiology, University of Southern Denmark, Odense, Denmark.

出版信息

New Microbiol. 2017 Apr;40(2):146-147. Epub 2017 Mar 1.

PMID:28255602

Abstract

We have previously shown that the phenothiazine, thioridazine, acts in synergy with the beta-lactam antibiotic, dicloxacillin, to kill methicillin-resistant Staphylococcus aureus. In this study, we investigated whether synergy by combining these two drugs could also be observed in vancomycin intermediate susceptible S. aureus (VISA) and methicillin-resistant Staphylococcus epidermidis (MRSE). Synergy was observed in three of four tested VISA strains, suggesting that the thickening of cell wall does not interfere with the effects of thioridazine. In S. epidermidis, no synergy was observed in all tested strains, suggesting that synergy by combining thioridazine and dicloxacillin is isolated to S. aureus species.

摘要

我们之前已经表明，吩噻嗪类药物硫利达嗪与β-内酰胺类抗生素双氯西林协同作用，可杀死耐甲氧西林金黄色葡萄球菌。在本研究中，我们调查了在万古霉素中介敏感金黄色葡萄球菌（VISA）和耐甲氧西林表皮葡萄球菌（MRSE）中，联合使用这两种药物是否也能观察到协同作用。在四个测试的VISA菌株中有三个观察到了协同作用，这表明细胞壁增厚并不干扰硫利达嗪的作用。在表皮葡萄球菌中，所有测试菌株均未观察到协同作用，这表明硫利达嗪和双氯西林联合产生的协同作用仅限于金黄色葡萄球菌属。