血清素给药对大鼠睾丸和附睾中血管紧张素转换酶的影响。

Changes in angiotensin converting enzyme in testes and epididymis of rat due to serotonin administration.

作者信息

Singh U S, Kumar M V, Panda J N

机构信息

Division of Biochemistry and Food Science, IVRI, Izatnagar/India.

出版信息

Andrologia. 1987 Mar-Apr;19(2):153-6. doi: 10.1111/j.1439-0272.1987.tb01876.x.

DOI:10.1111/j.1439-0272.1987.tb01876.x

PMID:2825565

Abstract

Effect of exogenous serotonin and blockade of its endogenous production on Angiotensin Converting Enzyme (ACE) in testes and epididymis was studied. Serotonin (30 mg/kg) and p-chlorophenylalanine (100 mg/kg) were injected for 4 and 3 days respectively. Serotonin reduced the weights of testes, seminal vesicle and ventral prostate whereas epididymal weight increased due to fluid accumulation. ACE was significantly reduced in tissue and fluid fractions of testes and epididymis of serotonin treated rats. pCPA had no effect on ACE levels. Serotonin seems to have direct effect on epididymis also.

摘要

研究了外源性血清素及其内源性生成的阻断对睾丸和附睾中血管紧张素转换酶（ACE）的影响。分别注射血清素（30毫克/千克）和对氯苯丙氨酸（100毫克/千克），持续4天和3天。血清素降低了睾丸、精囊和腹侧前列腺的重量，而附睾重量因液体蓄积而增加。血清素处理的大鼠睾丸和附睾的组织和液体部分中ACE显著降低。对氯苯丙氨酸对ACE水平无影响。血清素似乎对附睾也有直接作用。