Dept of Nuclear Medicine & PET Centre, Institute of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Unit of Psychooncology and Health psychology, Dept of Psychology and Behavioral Sciences, Aarhus University, Aarhus, Denmark.
Mov Disord. 2017 Jun;32(6):922-927. doi: 10.1002/mds.26961. Epub 2017 Mar 3.
Alzheimer's disease copathology is common in PD at autopsy. In non-PD subjects with mild cognitive impairment, tau depositions can be detected using 18F-AV-1451 PET. We hypothesized that 18F-AV-1451 PET would show tau aggregation in PD with mild cognitive impairment and correlate with cognitive dysfunction.
To describe tau aggregation in PD patients.
Twenty-six PD patients and 23 controls had 18F-AV-1451 PET and neuropsychological assessment to detect mild cognitive impairment.
Nine PD patients (35%) were identified with mild cognitive impairment. Regional analyses showed no significant differences between groups. Voxel-wise analyses showed no correlation with cognitive domain z-scores within patients. One patient with mild cognitive impairment was estimated Braak tau stage 5; all other patients were stage 0.
Our results indicate that tau pathology, as detected by 18F-AV-1451, is uncommon in PD with mild cognitive impairment and shows no significant correlation with cognitive dysfunction at this stage. © 2017 International Parkinson and Movement Disorder Society.
阿尔茨海默病的共病病理学在尸检的 PD 中很常见。在轻度认知障碍的非 PD 受试者中，使用 18F-AV-1451 PET 可以检测到 tau 沉积物。我们假设 18F-AV-1451 PET 将显示 PD 伴轻度认知障碍中的 tau 聚集，并与认知功能障碍相关。
描述 PD 患者的 tau 聚集情况。
26 名 PD 患者和 23 名对照者进行了 18F-AV-1451 PET 和神经心理学评估，以检测轻度认知障碍。
9 名 PD 患者（35%）被诊断为轻度认知障碍。组间无明显差异。体素分析显示，患者内认知域 z 分数与认知域 z 分数无相关性。一名轻度认知障碍患者的 tau 病理被估计为 Braak 第 5 期；所有其他患者均为 0 期。
我们的结果表明，18F-AV-1451 检测到的 tau 病理学在 PD 伴轻度认知障碍中并不常见，并且在该阶段与认知功能障碍无明显相关性。国际帕金森病和运动障碍学会 2017 年。
