Department of Nephrology, Tianjin First Center Hospital, Tianjin, CO300192, China.
Department of Nephrology, Tianjin Union Medicine Center, Tianjin, CO300000, China.
Sci Rep. 2017 Mar 3;7:43314. doi: 10.1038/srep43314.
The relationship between serum alkaline phosphatase (ALP) concentrations and mortality in peritoneal dialysis (PD) patients is rarely reported. We enrolled 667 PD patients in one PD centre in Taiwan to retrospectively examine the association between three ALP concentrations (baseline, time-averaged, time-dependent) and mortality over a 5-year period (2011-2015). Baseline data collection included demographics, clinical, and laboratory parameters. Multivariable-adjusted Cox models were used to analyse the association. Four ALP quartiles were defined at the baseline: ≤62, 63-82, 83-118, and ≥119 U/L. Of 667 patients, 65 patients died, of which 8 patients died due to cardiovascular disease. Females were predominant in the higher ALP quartiles, and 24-h urine volume was significantly proportionately decreased in the higher ALP quartiles. ALP quartiles expressed by the three models were not associated with all-cause or cardiovascular mortalities after adjusting for demographics, liver function, bone metabolism, mortality, hemoglobin, and 24-h urine volume. In conclusion, ALP concentrations were not associated with death risk in PD patients over the 5-year period.
血清碱性磷酸酶（ALP）浓度与腹膜透析（PD）患者死亡率之间的关系很少有报道。我们在台湾的一个 PD 中心纳入了 667 例 PD 患者，回顾性分析了在 5 年期间（2011-2015 年）三种 ALP 浓度（基线、时间平均、时间依赖）与死亡率之间的关系。基线数据收集包括人口统计学、临床和实验室参数。采用多变量调整 Cox 模型分析相关性。在基线时将 ALP 分为四个四分位区间：≤62、63-82、83-118 和≥119U/L。667 例患者中有 65 例死亡，其中 8 例死于心血管疾病。女性在较高的 ALP 四分位数中占优势，较高的 ALP 四分位数组 24 小时尿量显著减少。在调整了人口统计学、肝功能、骨代谢、死亡率、血红蛋白和 24 小时尿量等因素后，三种模型表示的 ALP 四分位数与全因死亡率或心血管死亡率均无相关性。总之，在 5 年期间，ALP 浓度与 PD 患者的死亡风险无关。
