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复杂妊娠的多学科治疗方法。

Multidisciplinary Approach to Complicated Pregnancy.

作者信息

Borovac Josip Andelo, Bozic Josko, Ticinovic Kurir Tina, Zaja Nikola, Kolic Kresimir, Hrboka Vedran

机构信息

From the Department of Pathophysiology, University of Split School of Medicine, Split, the Department of Internal Medicine, University Hospital Center Split, Split, University Psychiatric Hospital Vrapce, University of Zagreb School of Medicine, Zagreb, the Clinical Department of Diagnostic and Interventional Radiology University Hospital Center Split, Split, and the Department of Gynecology and Obstetrics, University Hospital Center Split, Split, Croatia.

出版信息

South Med J. 2017 Mar;110(3):154-160. doi: 10.14423/SMJ.0000000000000618.

DOI:10.14423/SMJ.0000000000000618
PMID:28257538
Abstract

A nulliparous pregnant woman in her mid-20s and in the 32nd week of gestation presented to the emergency department with severe headache and vomiting. She had an uneventful medical history; however, the physical examination upon hospital admission revealed a hypertensive emergency, papilledema, and 2+ dipstick proteinuria. Upon establishing the diagnosis of preeclampsia, aggressive therapy with corticosteroids, antihypertensive medication, and seizure prophylaxis was initiated. Hemodynamic stability was achieved within 24 hours and the patient remained in the observation unit located within the gynecology clinic. On the ninth day postadmission, however, her condition abruptly deteriorated and advanced to imminent eclampsia, accompanied by transient vision loss, altered mental status, and acute hypertensive crisis. After the patient underwent successful emergent delivery via caesarean section, a laboratory workup revealed hemolysis, elevated liver enzymes, and low platelet count, suggesting HELLP syndrome, a serious complication of eclampsia. This patient concurrently developed posterior reversible encephalopathy syndrome, which was confirmed by magnetic resonance imaging and acute respiratory distress syndrome (the latter presented with diffuse bilateral infiltrates on x-ray and developing pulmonary edema in the absence of cardiac etiology). Because of these life-threatening dynamics, the patient was transferred to the intensive care unit for further treatment. This case is a rare cascade of life-threatening complications that developed in a patient and required skillful multidisciplinary decision making and experienced management within an acute critical care setting. The final outcome of the treatment and intensive care was successful because both the patient and child survived and had no chronic or debilitating sequelae.

摘要

一名25岁左右、孕32周的初产妇因严重头痛和呕吐被送往急诊科。她既往病史无异常;然而,入院时体格检查发现高血压急症、视乳头水肿和尿蛋白定性2+。在确诊为先兆子痫后,开始积极使用皮质类固醇、抗高血压药物并预防癫痫发作。24小时内实现了血流动力学稳定,患者留在妇科诊所的观察病房。然而,入院后第9天,她的病情突然恶化,发展为即将发生的子痫,伴有短暂视力丧失、精神状态改变和急性高血压危机。患者通过剖宫产成功紧急分娩后,实验室检查显示溶血、肝酶升高和血小板计数降低,提示为HELLP综合征,这是子痫的一种严重并发症。该患者同时并发了后部可逆性脑病综合征,经磁共振成像确诊,还并发了急性呼吸窘迫综合征(后者在X线检查中表现为双侧弥漫性浸润,且在无心脏病因的情况下出现肺水肿)。由于这些危及生命的情况,患者被转至重症监护病房接受进一步治疗。该病例是一名患者身上罕见地相继出现一系列危及生命的并发症,需要在急性重症监护环境中进行熟练的多学科决策和经验丰富的管理。治疗和重症监护的最终结果是成功的,因为患者和婴儿均存活,且没有慢性或致残性后遗症。

相似文献

1
Multidisciplinary Approach to Complicated Pregnancy.复杂妊娠的多学科治疗方法。
South Med J. 2017 Mar;110(3):154-160. doi: 10.14423/SMJ.0000000000000618.
2
Cortical blindness, a rare complication of pre-eclampsia.皮质盲是子痫前期的一种罕见并发症。
J Emerg Med. 2005 Oct;29(3):295-7. doi: 10.1016/j.jemermed.2005.03.008.
3
Hypertensive disorders of pregnancy.妊娠期高血压疾病
Postgrad Med. 2009 Mar;121(2):69-76. doi: 10.3810/pgm.2009.03.1978.
4
Acute cortical blindness in preeclampsia--a case of reversible posterior encephalopathy syndrome.子痫前期的急性皮质盲——一例可逆性后部脑病综合征病例
Ginekol Pol. 2012 Jun;83(6):469-72.
5
Management of pre-eclampsia: issues for anaesthetists.子痫前期的处理:麻醉医师关注的问题。
Anaesthesia. 2012 Sep;67(9):1009-20. doi: 10.1111/j.1365-2044.2012.07195.x. Epub 2012 Jun 26.
6
Extensive hepatic infarction in severe preeclampsia as part of the HELLP syndrome (hemolysis, elevated liver enzymes, and low platelets): evolution of CT findings and successful treatment with plasma exchange therapy.严重先兆子痫中的广泛肝梗死,作为 HELLP 综合征(溶血、肝酶升高和血小板减少)的一部分:CT 表现的演变和血浆置换治疗的成功。
Taiwan J Obstet Gynecol. 2012 Sep;51(3):418-20. doi: 10.1016/j.tjog.2012.07.018.
7
[Peripartum cardiomyopathy and preeclampsia complicated with HELLP syndrome--a case report].[围产期心肌病合并先兆子痫并发HELLP综合征——病例报告]
Pol Arch Med Wewn. 2006 Oct;116(4):965-70.
8
Posterior reversible encephalopathy syndrome in patient of severe preeclampsia with Hellp syndrome immediate postpartum.重度子痫前期合并产后即刻发生的HELLP综合征患者的后部可逆性脑病综合征
Pan Afr Med J. 2015 May 26;21:60. doi: 10.11604/pamj.2015.21.60.5546. eCollection 2015.
9
Severe pre-eclampsia and hypertensive crises.重度子痫前期和高血压危象。
Best Pract Res Clin Obstet Gynaecol. 2013 Dec;27(6):877-84. doi: 10.1016/j.bpobgyn.2013.07.003. Epub 2013 Aug 17.
10
Do not forget about HELLP!不要忘记 HELLP!
BMJ Case Rep. 2011 Oct 28;2011:bcr0820114693. doi: 10.1136/bcr.08.2011.4693.

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