Creative Research Initiatives Center for Chromatin Dynamics, School of Biological Sciences, Seoul National University, Seoul 08826, South Korea.
Department of Biological Sciences, Sookmyung Women's University, Seoul 04310, South Korea.
Mol Cell. 2017 Mar 2;65(5):781-785. doi: 10.1016/j.molcel.2016.12.027.
Autophagy is an evolutionarily conserved catabolic process. Although the components of autophagy in cytoplasm have been well-studied, the molecular basis for the epigenetic regulation of autophagy is poorly understood. It is becoming more important to propose a "whole-cell view" of autophagy embracing both cytoplasmic and nuclear events. Thus, it is great timing to summarize current status and discuss future direction.
自噬是一种进化上保守的分解代谢过程。虽然细胞质中自噬的成分已经得到了很好的研究，但自噬的表观遗传调控的分子基础还知之甚少。提出一个包含细胞质和核事件的“全细胞视角”的自噬观点变得越来越重要。因此，现在是总结现状和讨论未来方向的好时机。
