Lauder S, Cosgrove V E, Gliddon E, Grimm D, Dodd S, Berk L, Castle D, Suppes T S, Berk M
Department of Psychiatry, University of Melbourne, Parkville, Australia; Federation University Australia, Ballarat, Australia.
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, United States; Bipolar and Depression Research Program, VA Palo Alto Health Care System, United States.
Contemp Clin Trials. 2017 May;56:18-24. doi: 10.1016/j.cct.2017.02.008. Epub 2017 Feb 28.
MoodSwings 2.0 is a self-guided online intervention for bipolar disorder. The intervention incorporates technological improvements on an earlier validated version of the intervention (MoodSwings 1.0). The previous MoodSwings trial provides this study with a unique opportunity to progress previous work, whilst being able to take into consideration lesson learnt, and technological enhancements. The structure and technology of MoodSwings 2.0 are described and the relevance to other online health interventions is highlighted. An international team from Australia and the US updated and improved the programs content pursuant to changes in DSM-5, added multimedia components and included larger numbers of participants in the group discussion boards. Greater methodological rigour in this trial includes an attention control condition, quarterly telephone assessments, and red flag alerts for significant clinical change. This paper outlines these improvements, including additional security and safety measures. A 3 arm RCT is currently evaluating the enhanced program to assess the efficacy of MS 2.0; the primary outcome is change in depressive and manic symptoms. To our knowledge this is the first randomized controlled online bipolar study with a discussion board attention control and meets the key methodological criteria for online interventions.
情绪波动2.0是一种针对双相情感障碍的自主引导式在线干预方案。该干预方案在早期经过验证的干预版本（情绪波动1.0）基础上进行了技术改进。之前的情绪波动试验为这项研究提供了一个独特的机会，既能推进之前的工作，又能考虑到吸取的经验教训和技术改进。本文描述了情绪波动2.0的结构和技术，并强调了其与其他在线健康干预措施的相关性。来自澳大利亚和美国的一个国际团队根据《精神疾病诊断与统计手册》第5版的变化更新并改进了项目内容，增加了多媒体组件，并在小组讨论板中纳入了更多参与者。该试验在方法上更加严谨，包括设置注意力控制组、每季度进行电话评估以及对重大临床变化设置红旗警报。本文概述了这些改进措施，包括额外的安全保障措施。一项三臂随机对照试验目前正在评估这个强化版方案，以评估情绪波动2.0的疗效；主要结果是抑郁和躁狂症状的变化。据我们所知，这是第一项设有讨论板注意力控制组的随机对照在线双相情感障碍研究，符合在线干预的关键方法学标准。
