Kiang Tony K L, Sherwin Catherine M T, Spigarelli Michael G, Ensom Mary H H
Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, British Columbia, Canada.
Division of Clinical Pharmacology & Clinical Trials Office, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, Utah, USA.
Clin Pharmacokinet. 2012 Aug;51(8):515-525. doi: 10.1007/BF03261928.
Population pharmacokinetic modelling is widely used within the field of clinical pharmacology as it helps to define the sources and correlates of pharmacokinetic variability in target patient populations and their impact upon drug disposition. This review focuses on the fundamentals of population pharmacokinetic modelling and provides an overview of the commonly available software programs that perform these functions.This review attempts to define the common, fundamental aspects of population pharmacokinetic modelling through a discussion of the literature describing the techniques and placing them in the appropriate context. An overview of the most commonly available software programs is also provided.Population pharmacokinetic modelling is a powerful approach where sources and correlates of pharmacokinetic variability can be identified in a target patient population receiving a pharmacological agent. There is a need to further standardize and establish the best approaches in modelling so that any model created can be systematically evaluated and the results relied upon. Various nonlinear mixed-effects modelling methods, packaged in a variety of software programs, are available today. When selecting population pharmacokinetic software programs, the consumer needs to consider several factors, including usability (e.g. user interface, native platform, price, input and output specificity, as well as intuitiveness), content (e.g. algorithms and data output) and support (e.g. technical and clinical).
群体药代动力学建模在临床药理学领域中被广泛应用，因为它有助于确定目标患者群体中药代动力学变异性的来源及其相关因素，以及它们对药物处置的影响。本综述聚焦于群体药代动力学建模的基本原理，并概述了执行这些功能的常用软件程序。本综述试图通过讨论描述这些技术的文献并将其置于适当的背景中，来界定群体药代动力学建模的常见基本方面。还提供了最常用软件程序的概述。群体药代动力学建模是一种强大的方法，可在接受药物治疗的目标患者群体中识别药代动力学变异性的来源及其相关因素。有必要进一步规范并确立建模的最佳方法，以便对所创建的任何模型进行系统评估并依赖其结果。如今有各种非线性混合效应建模方法，它们被封装在各种软件程序中。在选择群体药代动力学软件程序时，用户需要考虑几个因素，包括可用性（例如用户界面、原生平台、价格、输入和输出的特异性以及直观性）、内容（例如算法和数据输出）以及支持（例如技术和临床方面）。
