Muszalska Jadwiga, Zatoński Tomasz
Clinical Department of Otolaryngology, 4th Military Clinical Hospital with Outpatients Unit in Wroclaw, Poland.
Chair and Department of Otolaryngology, Head and Neck Surgery, Medical University of Wroclaw, Poland.
Pol Merkur Lekarski. 2017 Feb 20;42(248):87-89.
Inverted papilloma is a rare, benign sinonasal tumor. Its etiology is the most likely related to HPV infection. Inverted papilloma originates from the ciliated respiratory epithelium, typically from the lateral nasal wall. The tumor is characterized by endophytic growth inwards the stroma with adjacent tissues destruction. The clinical symptoms are non-specific, such as: unilateral obstruction of the nasal duct, rhinorrhoea, epistaxis and anosmia. The treatment consists in a complete surgical excision of the tumor. Inverted papilloma has a tendency to recurrence with incomplete resection and a potential to malignant transformation to squamous cell carcinoma. This manuscript presents a case of a young woman who suffered from recurrent epistaxis from ulceration of the mucous of the anterior part of the nasal septum. The patient in the interview had indicated the symptoms since six months and unsuccessful treatment with cetirizine. The woman was qualified to a surgical removal of the lesion with a transnasal approach. The histopahtological examination of the sample revealed Papilloma inversum. One-year follow up did not disclose the recurrence of the tumor.
内翻性乳头状瘤是一种罕见的鼻窦良性肿瘤。其病因最可能与HPV感染有关。内翻性乳头状瘤起源于纤毛呼吸上皮，通常来自鼻侧壁。该肿瘤的特征是向基质内内生性生长并伴有相邻组织破坏。临床症状不具特异性，如：单侧鼻道阻塞、流涕、鼻出血和嗅觉减退。治疗方法是完整手术切除肿瘤。内翻性乳头状瘤在切除不完全时有复发倾向，并有恶变成为鳞状细胞癌的可能。本文报告了一例年轻女性因鼻中隔前部黏膜溃疡反复鼻出血的病例。该患者在问诊中表示症状已持续六个月，且使用西替利嗪治疗无效。该女性接受了经鼻手术切除病变。样本的组织病理学检查显示为内翻性乳头状瘤。一年的随访未发现肿瘤复发。
