脾脏中滤泡性淋巴瘤转化为弥漫性大B细胞淋巴瘤：F-FDG PET/CT及组织学检查中两者同时出现

Follicular lymphoma transforming into diffuse large B-cell lymphoma in spleen: Simultaneous appearance of both on F-FDG PET/CT and histology.

作者信息

Makis William, Ciarallo Anthony, Petrogiannis-Haliotis Tina, Rosenberg Arthur, Probst Stephan

机构信息

Department of Diagnostic Imaging, Cross Cancer Institute, 11560 University Ave NW, Edmonton, Alberta, T6G 1Z2, Canada.

Department of Nuclear Medicine, MUHC McGill University Health Centre, Glen Site, 1001 Boul Decarie, Montreal, Quebec, H4A 3J1, Canada.

出版信息

Clin Imaging. 2017 May-Jun;43:88-92. doi: 10.1016/j.clinimag.2017.02.004. Epub 2017 Feb 21.

DOI:10.1016/j.clinimag.2017.02.004

PMID:28259031

Abstract

Low grade lymphoma may transform into a more aggressive lymphoma and this transformation is usually associated with a poor outcome. A 65year old man presented with two metabolically active splenic lesions on a staging [18F] fluoro-2-deoxy-d-glucose (F-FDG) positron emission tomography/computed tomography (PET/CT). Histologic evaluation post splenectomy confirmed the presence of two clonally related lymphomas: a follicular lymphoma (FL) and a diffuse large B-cell lymphoma (DLBCL). Molecular genetic studies confirmed that the DLBCL lesions arose from a pre-existing FL. We present the F-FDG PET/CT imaging characteristics of both lymphoma types which were simultaneously present in the spleen.

摘要

低度恶性淋巴瘤可能会转化为侵袭性更强的淋巴瘤，这种转化通常与不良预后相关。一名65岁男性在分期[18F]氟代脱氧葡萄糖（F-FDG）正电子发射断层扫描/计算机断层扫描（PET/CT）检查中发现脾脏有两个代谢活跃的病灶。脾切除术后的组织学评估证实存在两种克隆相关的淋巴瘤：滤泡性淋巴瘤（FL）和弥漫性大B细胞淋巴瘤（DLBCL）。分子遗传学研究证实，DLBCL病灶起源于先前存在的FL。我们展示了同时存在于脾脏中的两种淋巴瘤类型的F-FDG PET/CT成像特征。