中枢给予α-和γ2-黑素细胞刺激素对大鼠下丘脑血流自动调节的影响。

Influence of centrally administered alpha- and gamma 2-melanocyte-stimulating hormone on hypothalamic blood flow autoregulation in the rat.

作者信息

Sandor P, de Jong W, Cox-van Put J, de Wied D

机构信息

Experimental Research Department, Semmelweis University Medical School, Budapest, Hungary.

出版信息

Brain Res. 1987 Oct 20;424(1):189-92. doi: 10.1016/0006-8993(87)91209-1.

DOI:10.1016/0006-8993(87)91209-1

PMID:2825914

Abstract

The effect of intracerebroventricularly (i.c.v.) administered alpha-melanocyte-stimulating hormone (MSH) and gamma 2-MSH on hypothalamic blood flow autoregulation was studied in anesthetized rats at different levels of standardized arterial hypotension. Autoregulation was impaired upon i.c.v. administration of 5 micrograms/kg gamma 2-MSH while alpha-MSH caused no changes. Since this effect of gamma 2-MSH was identical to that produced by i.c.v. naloxone in the same model, gamma 2-MSH may be a functional antagonist of central opioid mechanisms participating in the control of cerebral blood flow autoregulation.

摘要

在麻醉大鼠处于不同程度的标准化动脉低血压状态下，研究了脑室内（i.c.v.）注射α-黑素细胞刺激素（MSH）和γ2-MSH对下丘脑血流自动调节的影响。脑室内注射5微克/千克γ2-MSH会损害自动调节功能，而α-MSH则无此作用。由于γ2-MSH在同一模型中的这种作用与脑室内注射纳洛酮所产生的作用相同，γ2-MSH可能是参与控制脑血流自动调节的中枢阿片样物质机制的功能性拮抗剂。