从翠雀花中分离出的一种新的二萜生物碱。

A new diterpenoid alkaloid isolated from Delphinium caeruleum.

作者信息

Lin Chao-Zhan, Liu Zhu-Jie, Bairi Zeren-Dawa, Zhu Chen-Chen

机构信息

Institute of Clinical Pharmacology, Guangzhou University of Chinese Medicine, Guangzhou 510405, China.

Tibetan Traditional Medical College, Lasa 850000, China.

出版信息

Chin J Nat Med. 2017 Jan;15(1):45-48. doi: 10.1016/S1875-5364(17)30007-9.

DOI:10.1016/S1875-5364(17)30007-9

PMID:28259252

Abstract

The present study was designed to determine the chemical constituents of Delphinium caeruleum Jacq. ex Camb.. The chemical constituents were isolated and purified by column chromatography with silica gel, ODS, and Sephadex LH-20. Their structures were elucidated by IR, MS, and NMR. Ten compounds were obtained and identified as caerudelphinine A (1), lycoctonine (2), talitine B (3), talitine A (4), talitine C (5), tatsienine-V (6), d-magnoflorine (7), 2-trimethyl-ammonio-3-(3-indolyl) propionate (8), vakhmatine (9), and delatisine (10). Compound 1 was a new lycoctonine-type C19-diterpenoid alkaloid, and compounds 4-10 were isolated from this plant for the first time.

摘要

本研究旨在确定蓝翠雀花（Delphinium caeruleum Jacq. ex Camb.）的化学成分。通过硅胶柱色谱、ODS柱色谱和葡聚糖凝胶LH - 20柱色谱对化学成分进行分离和纯化。通过红外光谱（IR）、质谱（MS）和核磁共振（NMR）对其结构进行解析。共获得10个化合物，分别鉴定为翠雀碱A（1）、狼毒素（2）、塔利替宁B（3）、塔利替宁A（4）、塔利替宁C（5）、紫堇达明碱 - V（6）、d - 木兰碱（7）、2 - 三甲基铵基 - 3 -（3 - 吲哚基）丙酸酯（8）、瓦赫马汀（9）和翠雀拉亭碱（10）。化合物1是一种新的狼毒素型C19 - 二萜生物碱，化合物4 - 10首次从该植物中分离得到。