Nizam Naveeda, Mazhar Farida, Abbas Khawar, Aziz Tahir, Zafar Mirza Naqir, Mohsin Rehan, Ali Bux, Shahzad Asad, Imran Mohammed, Rizvi Syed Adibul Hasan
Department of Medical Social Welfare, Sindh Institute of Urology and Transplantation, Karachi, Pakistan.
Exp Clin Transplant. 2017 Feb;15(Suppl 1):76-78. doi: 10.6002/ect.mesot2016.O63.
Kidney paired exchange is an established method of overcoming incompatibility in donor-recipient pairs and expanding the living-donor pool. It is infrequently performed in developing countries. We report the first kidney paired exchange in Pakistan, successfully performed at our center. One donor-recipient pair consisted of a 38-year-old female recipient (blood type, B positive) and her 40-year-old husband (A positive) as the potential donor. The second pair consisted of a 30-year-old male recipient (A positive) and his 30-year-old wife (B positive) as the potential donor. The donors were exchanged with the recipients, and both pairs were antigen matched for human leukocyte antigen A and human leukocyte antigen DR. Luminex antibody screening was negative, as were the crossmatches for T and B cells and for IgG and IgM. The transplant procedures and recoveries proceeded uneventfully. The recipients are maintaining serum creatinine levels around 0.78 mg/dL and 0.90 mg/dL, 1 year after transplant. Kidney paired exchange is a relatively low-cost option for overcoming the barrier of incompatibility in a resource-constrained setting.
