Blue J T, French T W, Kranz J S
Department of Pathology, New York State College of Veterinary Medicine, Cornell University, Ithaca 14853.
Cornell Vet. 1988 Jan;78(1):21-42.
Sixty cats with hematologic abnormalities indicative of non-lymphoid hematopoietic neoplasia were classified into two groups, myelodysplastic syndromes (MDS) and acute myelogenous leukemias (AML), using criteria developed for human patients with similar diseases. Cats with myeloblast counts in bone marrow of less than 30% were classed as MDS and cats with myeloblast counts of 30% or greater were classed as AML. The clinical, laboratory, and postmortem findings in each group were described and compared. Clinical signs of disease were similar in both groups, the most common being inappetance, lethargy, and weakness. Non-regenerative anemia, macrocytosis, neutropenia, and thrombocytopenia were frequent hemogram abnormalities in both groups. Diagnostically useful differences in physical and peripheral blood findings were a higher prevalence of splenomegaly and/or hepatomegaly, thrombocytopenia, and severe anemia in the AML group. Circulating myeloblasts were found only in cats in the AML group. Outcome of disease was similar in both groups; 85% of the cats in each group died or were euthanatized within one week of diagnosis. In cats that were necropsied, extramedullary leukemic infiltrates were found in all cats in the AML group and in none of the cats in the MDS group.
60只出现提示非淋巴细胞造血肿瘤血液学异常的猫，根据为患有类似疾病的人类患者制定的标准，被分为骨髓增生异常综合征（MDS）和急性髓性白血病（AML）两组。骨髓中原始粒细胞计数低于30%的猫被归类为MDS，原始粒细胞计数为30%或更高的猫被归类为AML。描述并比较了每组的临床、实验室和尸检结果。两组的疾病临床症状相似，最常见的是食欲不振、嗜睡和虚弱。两组血常规异常均常见非再生性贫血、大红细胞症、中性粒细胞减少和血小板减少。AML组在体格检查和外周血检查结果中具有诊断意义的差异是脾肿大和/或肝肿大、血小板减少和严重贫血的发生率更高。仅在AML组的猫中发现循环原始粒细胞。两组的疾病结局相似；每组85%的猫在诊断后一周内死亡或被安乐死。在接受尸检的猫中，AML组的所有猫均发现髓外白血病浸润，而MDS组的猫均未发现。
