碘化物介导的N-芳基烯胺电催化分子内氧化环化反应生成取代吲哚。
Electrocatalytic intramolecular oxidative annulation of N-aryl enamines into substituted indoles mediated by iodides.
作者信息
Tang Shan, Gao Xinlong, Lei Aiwen
机构信息
College of Chemistry and Molecular Sciences, Institute for Advanced Studies (IAS), Wuhan University, Wuhan 430072, Hubei, China.
出版信息
Chem Commun (Camb). 2017 Mar 16;53(23):3354-3356. doi: 10.1039/c7cc00410a.
An electrocatalytic reaction protocol is developed for achieving intramolecular dehydrogenative annulation of N-aryl enamines. It offers a simple and efficient way for the synthesis of indoles in an undivided cell. Good to excellent yields are obtained under oxidant-free and transition-metal-free conditions. Moreover, imidazo[1,2-a]pyridines could also be produced when N-pyridyl enamines were used as the substrates.
开发了一种用于实现N-芳基烯胺分子内脱氢环化的电催化反应方案。它为在无隔膜电解池中合成吲哚提供了一种简单有效的方法。在无氧化剂和无过渡金属的条件下可获得良好至优异的产率。此外，当使用N-吡啶基烯胺作为底物时，也可以制备咪唑并[1,2-a]吡啶。
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