博克有些地方我们还没有搞懂。
There is something about BOK we just don't get yet.
机构信息
Division of Developmental Immunology, BIOCENTER, Medical University of Innsbruck, Innsbruck, Austria.
Tyrolean Cancer Research Institute, Innsbruck, Austria.
出版信息
FEBS J. 2017 Mar;284(5):708-710. doi: 10.1111/febs.14031.
PMID:28262002
Abstract
Fernández-Marrero and colleagues show in their work that the proapoptotic BCL-2 family member BOK can form large, stable pores in artificial liposomes. This can be enhanced by the proapoptotic protein cBID and is unaffected by the antiapoptotic BCL-X . Although BOK can bind to isolated mitochondria, it is unable to cause cytochrome c release even with the help of cBID.
摘要
费尔南德斯-马雷罗等人在他们的工作中表明，促凋亡的 BCL-2 家族成员 BOK 可以在人工脂质体中形成大而稳定的孔。这种作用可以被促凋亡蛋白 cBID 增强，并且不受抗凋亡蛋白 BCL-X 的影响。尽管 BOK 可以与分离的线粒体结合，但即使在 cBID 的帮助下，它也无法导致细胞色素 c 的释放。
Zotero 插件