Division of Developmental Immunology, BIOCENTER, Medical University of Innsbruck, Innsbruck, Austria.
Tyrolean Cancer Research Institute, Innsbruck, Austria.
FEBS J. 2017 Mar;284(5):708-710. doi: 10.1111/febs.14031.
Fernández-Marrero and colleagues show in their work that the proapoptotic BCL-2 family member BOK can form large, stable pores in artificial liposomes. This can be enhanced by the proapoptotic protein cBID and is unaffected by the antiapoptotic BCL-X . Although BOK can bind to isolated mitochondria, it is unable to cause cytochrome c release even with the help of cBID.
费尔南德斯-马雷罗等人在他们的工作中表明，促凋亡的 BCL-2 家族成员 BOK 可以在人工脂质体中形成大而稳定的孔。这种作用可以被促凋亡蛋白 cBID 增强，并且不受抗凋亡蛋白 BCL-X 的影响。尽管 BOK 可以与分离的线粒体结合，但即使在 cBID 的帮助下，它也无法导致细胞色素 c 的释放。
