Kesebir Sermin, Erdinç Boray, Tarhan Nevzat
Üsküdar University, NPİstanbul Neuropsychiatry Hospital, İstanbul, Turkey.
Üsküdar University, NPİstanbul Neuropsychiatry Hospital, İstanbul, Turkey.
Asian J Psychiatr. 2017 Feb;25:179-183. doi: 10.1016/j.ajp.2016.10.014. Epub 2016 Oct 26.
In the present study we aimed to investigate, whether an association between metabolic syndrome (MetS) and clinical features and affective temperaments exists or not in first manic episode of bipolar disorder (BD) and to clarify the prevalence and predictors of MetS.
A total of 150 patients who were received a diagnosis of bipolar disorder type I according to DSM-IV criteria and who were experiencing their first manic episode (FME) were screened consecutively for inclusion. NCEP ATP III formulated an operational definition of MetS based on the presence of three or more of the following characteristics: abdominal obesity (waist circumference), hypertriglyceridemia, low HDL or being on an antilipidemic agent, high blood pressure or being on an antihypertensive agent, and fasting hyperglycemia or being on antiglycemic agent. The patients who had been in remission period for at least 8 weeks were evaluated with SKIP-TURK and TEMPS-A. Remission was defined as YMRS score <5.
37 (32.5%) patients had a MetS. Previous depressive episode, seasonality, negative family history and childhood trauma are determined as the predictors of MetS. Anxious and irritable temperament scores were higher in MetS (+) patients.
According to our results, links between MetS and BD may also have been predicted by genetic and environmental factors.
在本研究中，我们旨在调查双相情感障碍（BD）首次躁狂发作时代谢综合征（MetS）与临床特征及情感气质之间是否存在关联，并阐明MetS的患病率及预测因素。
连续筛选出150例根据DSM-IV标准被诊断为I型双相情感障碍且正经历首次躁狂发作（FME）的患者纳入研究。美国国家胆固醇教育计划成人治疗组第三次报告（NCEP ATP III）基于以下三种或更多特征制定了MetS的操作定义：腹部肥胖（腰围）、高甘油三酯血症、低高密度脂蛋白或正在服用抗血脂药物、高血压或正在服用抗高血压药物、空腹血糖升高或正在服用抗血糖药物。对处于缓解期至少8周的患者使用SKIP-TURK和TEMPS-A进行评估。缓解定义为杨氏躁狂量表（YMRS）评分<5。
37例（32.5%）患者患有MetS。既往抑郁发作、季节性、阴性家族史和童年创伤被确定为MetS的预测因素。MetS（+）患者的焦虑和易怒气质得分较高。
根据我们的结果，MetS与BD之间的联系也可能由遗传和环境因素预测。
