来自兔骨骼肌的2A型蛋白磷酸酶的第二个催化亚基。
A second catalytic subunit of type-2A protein phosphatase from rabbit skeletal muscle.
作者信息
da Cruz e Silva O B, Cohen P T
机构信息
Department of Biochemistry, University of Dundee, Scotland.
出版信息
FEBS Lett. 1987 Dec 21;226(1):176-8. doi: 10.1016/0014-5793(87)80574-4.
A cDNA clone encoding a second type-2A protein phosphatase catalytic subunit (2A beta) was isolated from a rabbit skeletal muscle cDNA library constructed in lambda gt10. The deduced protein sequence (309 residues, 35.59 kDa) was 97% identical to that of phosphatase 2A alpha (309 residues, 35.58 kDa). At the nucleotide level, the two clones showed only 82% identity in the coding region. The results indicate the presence of at least two isoforms of protein phosphatase 2A in skeletal muscle.
从构建于λgt10的兔骨骼肌cDNA文库中分离出一个编码第二种2A 型蛋白磷酸酶催化亚基（2Aβ）的cDNA克隆。推导的蛋白质序列（309个氨基酸残基，35.59 kDa）与磷酸酶2Aα（309个氨基酸残基，35.58 kDa）的序列有97%的同一性。在核苷酸水平上，这两个克隆在编码区仅显示82%的同一性。结果表明骨骼肌中存在至少两种2A 型蛋白磷酸酶的同工型。
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