Chaitchik S, Kabakow B, De Chabon A, Jonson J J, Bar-Eyal A, Selzer G, Feuer E J, Keydar I, Hizi A
Department of Oncology, Tel-Aviv Medical Center, Israel.
Eur J Surg Oncol. 1987 Dec;13(6):499-504.
In order to analyze which features determine a poorer prognosis we undertook a study of 91 consecutive patients with pathological Stage I breast cancer operated on at Beth Israel Medical Center (1968-71). Tumor tissue slides were reviewed and features such as: tumor size, histologic type, nuclear grade, lymphocytic and perivenular lymphocytic infiltration, as well as sinus histiocytosis in the lymph nodes removed. Records were reviewed and classified according to age and ethnic background. Survival and recurrence data were recorded up to 14 years post-mastectomy. Also determined was the presence of an antigen, previously detected in certain human breast cancer tumor tissues, which has been found to cross-react immunologically with the 52,000 dalton major envelope protein of the mouse mammary tumor virus (MMTV--gp52). Ten-year cumulative disease-free survival was 0.65. Univariate analysis of survival within various factors revealed that the only statistically significant influencing factor was the presence or absence of the antigen. Factors such as perivenous lymphocytic infiltration, diffuse lymphoid infiltration and sinus histiocytosis in regional lymph nodes also showed trends in favor of improved survival but the sample may be too small for statistical significance. The presence or absence of the antigen was independent of the host immunological reaction. There was no relationship between localization of tumor, whether medial or lateral and survival, nor with presence or absence of antigen.
为了分析哪些特征预示预后较差，我们对贝斯以色列医疗中心（1968 - 1971年）连续收治的91例接受手术治疗的病理I期乳腺癌患者进行了研究。复查肿瘤组织切片，并观察如下特征：肿瘤大小、组织学类型、核分级、淋巴细胞及血管周围淋巴细胞浸润，以及切除淋巴结中的窦组织细胞增生。根据年龄和种族背景对记录进行复查和分类。记录乳房切除术后长达14年的生存和复发数据。还检测了一种抗原的存在情况，该抗原先前在某些人类乳腺癌肿瘤组织中被检测到，已发现它与小鼠乳腺肿瘤病毒（MMTV - gp52）的52,000道尔顿主要包膜蛋白发生免疫交叉反应。十年累积无病生存率为0.65。对各因素生存情况的单因素分析显示，唯一具有统计学显著影响的因素是抗原的有无。诸如血管周围淋巴细胞浸润、区域淋巴结弥漫性淋巴浸润和窦组织细胞增生等因素也显示出有利于提高生存率的趋势，但样本量可能太小，无统计学意义。抗原的有无与宿主免疫反应无关。肿瘤位于内侧还是外侧与生存情况无关，与抗原的有无也无关。
