钆特酸用于腕关节和膝关节软骨磁共振成像增强扫描（dGEMRIC）的可行性及其与 Gd-DTPA 的比较

Feasibility of gadoteric acid for delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) at the wrist and knee and comparison with Gd-DTPA.

机构信息

Department of Diagnostic and Interventional Radiology, University Hospital Heidelberg, Germany.

Department of Orthopedics and Trauma Surgery, University Hospital Heidelberg, Germany.

出版信息

J Magn Reson Imaging. 2017 Nov;46(5):1433-1440. doi: 10.1002/jmri.25688. Epub 2017 Mar 6.

DOI:10.1002/jmri.25688

PMID:28263424

Abstract

PURPOSE

To assess the feasibility of gadoteric acid for delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC) and to compare the dGEMRIC values obtained using gadoteric acid with those obtained by an equimolar dose of Gd-DTPA.

MATERIALS AND METHODS

At 3T, dGEMRIC of the wrist was performed twice using a T -weighted 3D-volumetric interpolated breath-hold examination sequence in 16 healthy volunteers (10 women; mean age 26.0 years) using gadoteric acid first and Gd-DTPA 3 weeks later. In addition, 24 patients with knee pain were examined using gadoteric acid (n = 12; seven women; mean age 45.8 years) or Gd-DTPA (n = 12; four women; mean age 47.1 years). T values, the relative decrease in T , and the delta R1 were compared using t-tests. Interobserver agreement was assessed using the intraclass correlation (ICC) between two independent readers.

RESULTS

At the wrist, there was no significant difference in delta R1 values (0.34 ± 0.10/s, 95% confidence interval [0.30;0.38]/s for gadoteric acid and 0.32 ± 0.09 [0.29;0.35]/s for Gd-DTPA, P = 0.24) or the relative decrease in T (0.25 ± 0.06 [0.29;0.35] msec for gadoteric acid and 0.24 ± 0.05 [0.22;0.27] msec for Gd-DTPA, P = 0.35). High observer agreement was found at precontrast (ICC = 0.87, P < 0.001) and postcontrast (ICC = 0.89, P < 0.001). Similarly, at the knee, there was no significant difference in delta R1 (0.39 ± 0.18 [0.32;0.47]/s for gadoteric acid and 0.41 ± 0.09 [0.38;0.45]/s for Gd-DTPA, P = 0.59) or the relative decrease in T (0.30 ± 0.10 [0.26;0.34] msec for gadoteric acid and 0.33 ± 0.05 [0.30;0.35] msec for Gd-DTPA, P = 0.28). High ICCs of 0.96 (P < 0.01) were noted both at precontrast and postcontrast.

CONCLUSION

dGEMRIC using gadoteric acid is feasible and yields comparable values when compared with Gd-DTPA.

LEVEL OF EVIDENCE

2 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2017;46:1433-1440.

摘要

目的

评估钆特酸在软骨延迟钆增强磁共振成像（dGEMRIC）中的可行性，并比较使用钆特酸和等摩尔剂量的 Gd-DTPA 获得的 dGEMRIC 值。

材料与方法

在 3T 下，16 名健康志愿者（10 名女性；平均年龄 26.0 岁）使用 T1 加权 3D 容积内插屏气检查序列进行腕关节两次 dGEMRIC 检查，首先使用钆特酸，3 周后使用 Gd-DTPA。此外，24 名膝关节疼痛患者分别使用钆特酸（n=12；7 名女性；平均年龄 45.8 岁）或 Gd-DTPA（n=12；4 名女性；平均年龄 47.1 岁）进行检查。使用 t 检验比较 T 值、T 的相对降低和 delta R1。使用两位独立读者之间的组内相关系数（ICC）评估观察者间的一致性。

结果

在腕关节，delta R1 值（0.34±0.10/s，95%置信区间[0.30；0.38]/s 为钆特酸和 0.32±0.09 [0.29；0.35]/s 为 Gd-DTPA，P=0.24）或 T 的相对降低（0.25±0.06 [0.29；0.35] msec 为钆特酸和 0.24±0.05 [0.22；0.27] msec 为 Gd-DTPA，P=0.35）均无显著差异。在预对比（ICC=0.87，P<0.001）和后对比（ICC=0.89，P<0.001）均有很高的观察者一致性。同样，在膝关节，delta R1（0.39±0.18 [0.32；0.47]/s 为钆特酸和 0.41±0.09 [0.38；0.45]/s 为 Gd-DTPA，P=0.59）或 T 的相对降低（0.30±0.10 [0.26；0.34] msec 为钆特酸和 0.33±0.05 [0.30；0.35] msec 为 Gd-DTPA，P=0.28）均无显著差异。在预对比和后对比时，ICC 均为 0.96（P<0.01），均有很高的一致性。