Parker Institute, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark.
Department of Radiology, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark.
J Magn Reson Imaging. 2018 Dec;48(6):1700-1706. doi: 10.1002/jmri.26190. Epub 2018 Aug 13.
Early cartilage changes in knee osteoarthritis (OA) can be assessed by both intravenous (i.v.) and intra-articular (i.a.) delayed gadolinium-enhanced MRI of cartilage (dGEMRIC).
To examine the relationship between i.a. dGEMRIC and delayed gadolinium-enhanced MRI of menisci (dGEMRIM), and to investigate if the approach can be used to assess the morphological degeneration of menisci in obese patients with knee OA.
Cross-sectional.
Eighty-five obese patients with knee OA.
FIELD STRENGTH/SEQUENCES: 1.5T. Inversion recovery sequence with four inversion times.
T relaxation times were calculated for posterior weight-bearing femoral cartilage and the posterior horns of the menisci. Meniscus degeneration sum score (0-2) was assessed as increased signal/no signal (1/0) and tear/no tear (1/0).
T relaxation times were compared using Student's t-test. Comparison of cartilage and meniscus T relaxation times was done by regression analysis. Analysis of variance (ANOVA) was used for comparison of meniscal T relaxation times among the three summed morphological scores (0-2). Statistical analyses were performed with a level of significance at 0.05.
For lateral menisci, morphology sum scores of 0, 1, and 2 were found in 13, 58, and 14 patients and for medial menisci in 2, 30, and 30 patients, respectively. Mean T relaxation times were 441 msec, 480 msec, and 497 msec for cartilage, lateral menisci, and medial menisci, respectively. T relaxation times for the menisci were similar (P = 0.53), and a weak correlation was found between dGEMRIC and dGEMRIM in the lateral compartments (R = 0.26). Comparing dGEMRIM between different morphology sum scores showed no differences (P > 0.4).
I.a. dGEMRIM showed no correlation between the degree of meniscal degeneration and meniscus T relaxation times. I.a. dGEMRIM do not seem to deliver useful information about meniscus degeneration to be suitable for clinical applications, but i.a. dGEMRIC may still be considered an alternative contrast-saving method for cartilage.
3 Technical Efficacy: Stage 3 J. Magn. Reson. Imaging 2018;48:1700-1706.
膝关节骨关节炎（OA）的早期软骨变化可以通过静脉内（iv）和关节内（ia）延迟钆增强 MRI 软骨（dGEMRIC）进行评估。
研究关节内 dGEMRIC 与半月板延迟钆增强 MRI（dGEMRIM）之间的关系，并探讨该方法是否可用于评估肥胖膝关节 OA 患者半月板的形态退变。
横断面研究。
85 例肥胖膝关节 OA 患者。
磁场强度/序列：1.5T。反转恢复序列，有四个反转时间。
计算后承重股骨软骨和半月板后角的 T 弛豫时间。半月板退变总和评分（0-2）为信号增加/无信号（1/0）和撕裂/无撕裂（1/0）。
使用学生 t 检验比较 T 弛豫时间。通过回归分析比较软骨和半月板的 T 弛豫时间。方差分析（ANOVA）用于比较三种总和形态评分（0-2）之间的半月板 T 弛豫时间。统计学分析的显著性水平为 0.05。
外侧半月板的 0、1 和 2 形态总和评分分别在 13、58 和 14 例患者中发现，内侧半月板分别在 2、30 和 30 例患者中发现。软骨、外侧半月板和内侧半月板的平均 T 弛豫时间分别为 441 msec、480 msec 和 497 msec。半月板的 T 弛豫时间相似（P = 0.53），外侧关节腔的 dGEMRIC 和 dGEMRIM 之间存在弱相关性（R = 0.26）。比较不同形态总和评分之间的 dGEMRIM 无差异（P > 0.4）。
关节内 dGEMRIM 显示半月板退变程度与半月板 T 弛豫时间之间无相关性。关节内 dGEMRIM 似乎不能提供有关半月板退变的有用信息，不适合临床应用，但关节内 dGEMRIC 仍可被视为替代对比节约的软骨方法。
3 技术功效：第 3 阶段 J. Magn. Reson. Imaging 2018;48:1700-1706.
