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Anticoagulant therapy with fondaparinux in a liver transplant patient with thrombosis and liver fibrosis: a case report.在一名患有血栓形成和肝纤维化的肝移植患者中使用磺达肝癸钠进行抗凝治疗：病例报告
Clin Case Rep. 2017 Feb 9;5(3):342-345. doi: 10.1002/ccr3.820. eCollection 2017 Mar.
2
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Use of fondaparinux for thromboprophylaxis in an unfractionated heparin-intolerant pregnant woman with thrombotic predisposition.在一名对普通肝素不耐受且有血栓形成倾向的孕妇中使用磺达肝癸钠进行血栓预防。
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The Therapeutic Potential of Anticoagulation in Organ Fibrosis.抗凝治疗在器官纤维化中的治疗潜力
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Fondaparinux is effective for acute portal vein thrombosis in decompensated cirrhotic patients.磺达肝癸钠对失代偿期肝硬化患者的急性门静脉血栓形成有效。
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本文引用的文献

1
Incidence and risk factors of deep vein thrombosis after liver transplantation.肝移植后深静脉血栓形成的发生率及危险因素
Transplant Proc. 2014 Dec;46(10):3564-9. doi: 10.1016/j.transproceed.2014.09.113.
2
De novo sirolimus and reduced-dose tacrolimus versus standard-dose tacrolimus after liver transplantation: the 2000-2003 phase II prospective randomized trial.肝移植后新西罗莫司联合小剂量他克莫司与标准剂量他克莫司的比较：2000-2003 年 II 期前瞻性随机试验。
Am J Transplant. 2014 Feb;14(2):356-66. doi: 10.1111/ajt.12543. Epub 2014 Jan 23.
3
Anticoagulation inhibits tumor cell-mediated release of platelet angiogenic proteins and diminishes platelet angiogenic response.抗凝抑制肿瘤细胞介导的血小板血管生成蛋白释放，并减弱血小板血管生成反应。
Blood. 2014 Jan 2;123(1):101-12. doi: 10.1182/blood-2013-02-485011. Epub 2013 Sep 24.
4
Review of the American College of Chest Physicians 2012 Guidelines for Anticoagulation Therapy and Prevention of Thrombosis.美国胸科医师学会 2012 年抗凝治疗与血栓预防指南综述。
Semin Hematol. 2013 Jul;50(3):251-8. doi: 10.1053/j.seminhematol.2013.06.005.
5
The role of hypercoagulability in liver fibrogenesis.高凝状态在肝纤维化形成中的作用。
Clin Res Hepatol Gastroenterol. 2011 Sep;35(8-9):526-33. doi: 10.1016/j.clinre.2011.03.011. Epub 2011 May 14.
6
The mean values of liver stiffness assessed by Acoustic Radiation Force Impulse elastography in normal subjects.正常受试者中通过声辐射力脉冲弹性成像评估的肝脏硬度平均值。
Med Ultrason. 2011 Mar;13(1):33-7.
7
One thousand consecutive primary liver transplants under tacrolimus immunosuppression: a 17- to 20-year longitudinal follow-up.他克莫司免疫抑制下连续 1000 例原发性肝移植：17 至 20 年的纵向随访。
Transplantation. 2011 May 15;91(9):1025-30. doi: 10.1097/TP.0b013e3182129215.
8
Differential inhibitory effect of fondaparinux on the procoagulant potential of intact monocytes and monocyte-derived microparticles.磺达肝癸钠对完整单核细胞和单核细胞衍生微粒体促凝潜能的差异抑制作用。
J Thromb Thrombolysis. 2010 Nov;30(4):412-8. doi: 10.1007/s11239-010-0490-4.
9
Safety and efficacy of anticoagulation therapy with low molecular weight heparin for portal vein thrombosis in patients with liver cirrhosis.低分子肝素抗凝治疗肝硬化患者门静脉血栓形成的安全性和有效性。
J Clin Gastroenterol. 2010 Jul;44(6):448-51. doi: 10.1097/MCG.0b013e3181b3ab44.
10
Clinical characteristics of Caroli's syndrome.卡罗里氏综合征的临床特征。
World J Gastroenterol. 2007 Apr 7;13(13):1934-7. doi: 10.3748/wjg.v13.i13.1934.

在一名患有血栓形成和肝纤维化的肝移植患者中使用磺达肝癸钠进行抗凝治疗：病例报告

Anticoagulant therapy with fondaparinux in a liver transplant patient with thrombosis and liver fibrosis: a case report.

作者信息

Cafolla Arturo, Gentile Giuseppe

机构信息

Department of Cellular Biotechnologies and Hematology Thrombosis Centre Sapienza University of Rome Rome Italy.

Department of Cellular Biotechnologies and Hematology Infectious Diseases Unit Sapienza University of Rome Rome Italy.

出版信息

Clin Case Rep. 2017 Feb 9;5(3):342-345. doi: 10.1002/ccr3.820. eCollection 2017 Mar.

DOI:10.1002/ccr3.820
PMID:28265403
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5331225/
Abstract

The treatment with fondaparinux is the effective and safe anticoagulant therapy in liver transplant patient on immunosuppressive therapy with arterial thrombosis, and it seems able to reduce liver fibrosis. Although this treatment is not generalizable, further prospective large studies need to confirm this case report.

摘要

对于接受免疫抑制治疗且发生动脉血栓形成的肝移植患者，磺达肝癸钠治疗是一种有效且安全的抗凝治疗方法，并且似乎能够减轻肝纤维化。尽管这种治疗方法无法推广，但需要进一步的前瞻性大型研究来证实本病例报告。