Magouliotis Dimitrios E, Tasiopoulou Vasiliki S, Sioka Eleni, Chatedaki Christina, Zacharoulis Dimitrios
Department of Surgery, University Hospital of Larissa, Larissa, Greece.
School of Health Sciences, Faculty of Medicine, University of Thessaly, Viopolis, Larissa, Greece.
Obes Surg. 2017 May;27(5):1345-1357. doi: 10.1007/s11695-017-2595-8.
We aim to review the available literature on obese patients treated with bariatric procedures, in order to assess their effect on the metabolic and gut microbiota profiles. A systematic literature search was performed in PubMed, Cochrane library, and Scopus databases, in accordance with the PRISMA guidelines. Twenty-two studies (562 patients) met the inclusion criteria. This study points to significant amelioration of postoperative levels of glucose, insulin, triglycerides, total cholesterol, LDL, HDL, HOMA-IR, food intake, and diabetes remission. Branched-chain amino acids (BCAAs) decreased, while trimethylamine-n-oxide (TMAO); glucagon-like peptide 1, 2 (GLP-1, GLP-2); and peptide YY (PYY) increased postoperatively. Postoperative gut microbiota was similar to that of lean and less obese objects. Well-designed randomized trials are necessary to further assess the host metabolic-microbial cross-talk after bariatric procedures.
我们旨在回顾有关接受减肥手术治疗的肥胖患者的现有文献，以评估其对代谢和肠道微生物群谱的影响。根据PRISMA指南，在PubMed、Cochrane图书馆和Scopus数据库中进行了系统的文献检索。22项研究（562名患者）符合纳入标准。本研究表明，术后血糖、胰岛素、甘油三酯、总胆固醇、低密度脂蛋白、高密度脂蛋白、胰岛素抵抗指数、食物摄入量和糖尿病缓解水平有显著改善。支链氨基酸（BCAAs）减少，而氧化三甲胺（TMAO）、胰高血糖素样肽1、2（GLP-1、GLP-2）和肽YY（PYY）术后增加。术后肠道微生物群与瘦人和肥胖程度较轻者相似。有必要进行精心设计的随机试验，以进一步评估减肥手术后宿主代谢与微生物之间的相互作用。
