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LASP-1 相互作用蛋白的生物信息学分析及其与 HBV 相关肝细胞癌的关系。

Bioinformatics analysis of the proteins interacting with LASP-1 and their association with HBV-related hepatocellular carcinoma.

机构信息

Jiangsu Key Laboratory of Brain Disease Bioinformation, Xuzhou Medical University, Xuzhou, Jiangsu, China.

Department of Pathogenic Biology and Immunology, Jiangsu Key Laboratory of Immunity and Metabolism, Xuzhou Medical University, Xuzhou, Jiangsu, China.

出版信息

Sci Rep. 2017 Mar 7;7:44017. doi: 10.1038/srep44017.

DOI:10.1038/srep44017
PMID:28266596
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5339786/
Abstract

LIM and SH3 domain protein (LASP-1) is responsible for the development of several types of human cancers via the interaction with other proteins; however, the precise biological functions of proteins interacting with LASP-1 are not fully clarified. Although the role of LASP-1 in hepatocarcinogenesis has been reported, the implication of LASP-1 interactors in HBV-related hepatocellular carcinoma (HCC) is not clearly evaluated. We obtained information regarding LASP-1 interactors from public databases and published studies. Via bioinformatics analysis, we found that LASP-1 interactors were related to distinct molecular functions and associated with various biological processes. Through an integrated network analysis of the interaction and pathways of LASP-1 interactors, cross-talk between different proteins and associated pathways was found. In addition, LASP-1 and several its interactors are significantly altered in HBV-related HCC through microarray analysis and could form a complex co-expression network. In the disease, LASP-1 and its interactors were further predicted to be regulated by a complex interaction network composed of different transcription factors. Besides, numerous LASP-1 interactors were associated with various clinical factors and related to the survival and recurrence of HBV-related HCC. Taken together, these results could help enrich our understanding of LASP-1 interactors and their relationships with HBV-related HCC.

摘要

LIM 和 SH3 域蛋白（LASP-1）通过与其他蛋白质相互作用，负责几种类型的人类癌症的发展；然而，与 LASP-1 相互作用的蛋白质的确切生物学功能尚未完全阐明。虽然已经报道了 LASP-1 在肝癌发生中的作用，但 LASP-1 相互作用蛋白在乙型肝炎病毒（HBV）相关肝细胞癌（HCC）中的意义尚未明确评估。我们从公共数据库和已发表的研究中获取了有关 LASP-1 相互作用蛋白的信息。通过生物信息学分析，我们发现 LASP-1 相互作用蛋白与不同的分子功能相关，并与各种生物学过程相关。通过对 LASP-1 相互作用蛋白的相互作用和途径的综合网络分析，发现了不同蛋白质之间的串扰和相关途径。此外，通过微阵列分析发现 LASP-1 及其几种相互作用蛋白在 HBV 相关 HCC 中发生显著改变，并能形成一个复杂的共表达网络。在疾病中，LASP-1 及其相互作用蛋白进一步被预测受到由不同转录因子组成的复杂相互作用网络的调控。此外，许多 LASP-1 相互作用蛋白与各种临床因素相关，并与 HBV 相关 HCC 的生存和复发相关。总之，这些结果有助于丰富我们对 LASP-1 相互作用蛋白及其与 HBV 相关 HCC 的关系的理解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/537c/5339786/3663efb6ff95/srep44017-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/537c/5339786/5c7f3962c9f0/srep44017-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/537c/5339786/83e21ba32054/srep44017-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/537c/5339786/88573d4ee653/srep44017-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/537c/5339786/6a7389cf1fb8/srep44017-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/537c/5339786/3663efb6ff95/srep44017-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/537c/5339786/5c7f3962c9f0/srep44017-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/537c/5339786/83e21ba32054/srep44017-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/537c/5339786/88573d4ee653/srep44017-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/537c/5339786/6a7389cf1fb8/srep44017-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/537c/5339786/3663efb6ff95/srep44017-f5.jpg

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