Zhang Jiaxing, Chen Ji, Fan Cunxiu, Li Jinqiang, Lin Jianzhong, Yang Tianhe, Fan Ming
1 Department of Physiology, Medical College of Xiamen University , Xiamen, China .
2 Department of Clinical Psychology, Gulangyu Sanatorium of PLA , Xiamen, China .
High Alt Med Biol. 2017 Mar;18(1):20-26. doi: 10.1089/ham.2016.0083. Epub 2017 Mar 7.
Zhang, Jiaxing, Ji Chen, Cunxiu Fan, Jinqiang Li, Jianzhong Lin, Tianhe Yang, and Ming Fan. Alteration of spontaneous brain activity after hypoxia-reoxygenation: A resting-state fMRI study. High Alt Med Biol. 18:20-26, 2017.-The present study was designed to investigate the effect of hypoxia-reoxygenation on the spontaneous neuronal activity in brain. Sixteen sea-level (SL) soldiers (20.5 ± 0.7 years), who garrisoned the frontiers in high altitude (HA) (2300-4400 m) for two years and subsequently descended to sea level for one to seven days, were recruited. Control group consisted of 16 matched SL natives. The amplitude of low-frequency fluctuations (ALFF) of regional brain functional magnetic resonance imaging signal in resting state and functional connectivity (FC) between brain regions was analyzed. HA subjects showed significant increases of ALFF at several sites within the bilateral occipital cortices and significant decreases of ALFF in the right anterior insula and extending to the caudate, putamen, inferior frontal orbital cortex, temporal pole, and superior temporal gyrus; lower ALFF values in the right insula were positively correlated with low respiratory measurements. The right insula in HA subjects had increases of FC with the right superior temporal gyrus, postcentral gyrus, rolandic operculum, supramarginal gyrus, and inferior frontal triangular area. We thus demonstrated that hypoxia-reoxygenation had influence on the spontaneous neuronal activity in brain. The decrease of insular neuronal activity may be related to the reduction of ventilatory drive, while the increase of FC with insula may indicate a central compensation.
张嘉兴、季晨、范存秀、李金强、林建忠、杨天和、范明。缺氧复氧后自发性脑活动的改变：一项静息态功能磁共振成像研究。《高原医学与生物学》。2017年；18(1)：20 - 26。本研究旨在探讨缺氧复氧对脑内自发性神经元活动的影响。招募了16名海平面（SL）士兵（20.5±0.7岁），他们在高海拔（HA）（2300 - 4400米）边境驻防两年，随后下到海平面1至7天。对照组由16名匹配的SL本地人组成。分析了静息状态下区域脑功能磁共振成像信号的低频波动幅度（ALFF）以及脑区之间的功能连接（FC）。HA组受试者双侧枕叶皮质内多个部位的ALFF显著增加，右侧前岛叶以及延伸至尾状核、壳核、额下回眶部皮质、颞极和颞上回的ALFF显著降低；右侧岛叶较低ALFF值与低呼吸测量值呈正相关。HA组受试者右侧岛叶与右侧颞上回、中央后回、中央 operculum、缘上回和额下三角区的FC增加。因此，我们证明了缺氧复氧对脑内自发性神经元活动有影响。岛叶神经元活动的降低可能与通气驱动的降低有关，而与岛叶FC的增加可能表明中枢性代偿。
