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使用铜标记的前列腺特异性膜抗原配体对前列腺癌进行成像

Imaging of Prostate Cancer Using Cu-Labeled Prostate-Specific Membrane Antigen Ligand.

作者信息

Singh Aviral, Kulkarni Harshad R, Baum Richard P

机构信息

THERANOSTICS Center for Molecular Radiotherapy and Molecular Imaging (PET/CT), ENETS Center of Excellence, Zentralklinik Bad Berka, Robert-Koch-Allee 9, Bad Berka 99437, Germany.

THERANOSTICS Center for Molecular Radiotherapy and Molecular Imaging (PET/CT), ENETS Center of Excellence, Zentralklinik Bad Berka, Robert-Koch-Allee 9, Bad Berka 99437, Germany.

出版信息

PET Clin. 2017 Apr;12(2):193-203. doi: 10.1016/j.cpet.2016.12.001. Epub 2017 Jan 31.

DOI:10.1016/j.cpet.2016.12.001
PMID:28267453
Abstract

Prostate cancer is the most common noncutaneous cancer among men, rendering the diagnosis and staging of significant medical and public interest. One of the most interesting developments in the application of nuclear oncology has been the development of novel diagnostic agents that are able to facilitate targeted therapies using the concept of theranostics. This review summarizes the current and emerging molecular imaging techniques for the investigation of patients with prostate cancer with emphasis on the potential of Cu-PSMA PET/CT in staging, restaging, and the application of theranostics.

摘要

前列腺癌是男性中最常见的非皮肤癌,其诊断和分期具有重大的医学和公共利益。核肿瘤学应用中最有趣的进展之一是新型诊断剂的开发,这些诊断剂能够利用治疗诊断学的概念促进靶向治疗。本综述总结了用于前列腺癌患者检查的当前和新兴分子成像技术,重点是Cu-PSMA PET/CT在分期、重新分期以及治疗诊断学应用方面的潜力。

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ATPase Copper Transporting Beta (ATP7B) Is a Novel Target for Improving the Therapeutic Efficacy of Docetaxel by Disulfiram/Copper in Human Prostate Cancer.
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